Gli and hedgehog in cancer:: Tumours, embryos and stem cells

被引：537
作者：
Altaba, AR
Sánchez, P
Dahmane, N
机构：
[1] NYU, Sch Med, Skirball Inst, Dev Genet Program, New York, NY 10016 USA
[2] NYU, Sch Med, Dept Cell Biol, New York, NY 10016 USA
[3] Univ Meditterannee, CNRS, Inst Dev Biol, UMR 6156, F-13288 Marseille, France
来源：
NATURE REVIEWS CANCER | 2002年 / 2卷 / 05期
关键词：
D O I：
10.1038/nrc796
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Do tumours arise from stem cells, or are they derived from more differentiated cells that, for some reason, begin to recapitulate developmental programmes? Inappropriate activation of the Sonic hedgehog-Gli signalling pathway occurs in several types of tumour, including those of the brain and the skin. Studies in these and other systems suggest that inappropriate function of the Gli transcription factors in stem or precursor cells might lead to the onset of a tumorigenic programme and that these factors are prime targets for anticancer therapies.
引用
收藏
页码：361 / 372
页数：12
相关论文
共 140 条
[21]   Gli/Zic factors pattern the neural plate by defining domains of cell differentiation [J].
Brewster, R ;
Lee, J ;
Altaba, ARI .
NATURE, 1998, 393 (6685) :579-583
[22]   Amphibian limb regeneration: Rebuilding a complex structure [J].
Brockes, JP .
SCIENCE, 1997, 276 (5309) :81-87
[23]   Monstrous attempts at adnexogenesis: regulating hair follicle progenitors through Sonic hedgehog signaling [J].
Callahan, CA ;
Oro, AE .
CURRENT OPINION IN GENETICS & DEVELOPMENT, 2001, 11 (05) :541-546
[24]   The transcription factor Snail controls epithelial-mesenchymal transitions by repressing E-cadherin expression [J].
Cano, A ;
Pérez-Moreno, MA ;
Rodrigo, I ;
Locascio, A ;
Blanco, MJ ;
del Barrio, MG ;
Portillo, F ;
Nieto, MA .
NATURE CELL BIOLOGY, 2000, 2 (02) :76-83
[25]   Cyclopia and defective axial patterning in mice lacking Sonic hedgehog gene function [J].
Chiang, C ;
Ying, LTT ;
Lee, E ;
Young, KE ;
Corden, JL ;
Westphal, H ;
Beachy, PA .
NATURE, 1996, 383 (6599) :407-413
[26]   Essential role for Sonic hedgehog during hair follicle morphogenesis [J].
Chiang, C ;
Swan, RZ ;
Grachtchouk, M ;
Bolinger, M ;
Ying, LTT ;
Robertson, EK ;
Cooper, MK ;
Gaffield, W ;
Westphal, H ;
Beachy, PA ;
Dlugosz, AA .
DEVELOPMENTAL BIOLOGY, 1999, 205 (01) :1-9
[27]   Essential role for oncogenic Ras in tumour maintenance [J].
Chin, L ;
Tam, A ;
Pomerantz, J ;
Wong, M ;
Holash, J ;
Bardeesy, N ;
Shen, Q ;
O'Hagan, R ;
Pantginis, J ;
Zhou, H ;
Horner, JW ;
Cordon-Cardo, C ;
Yancopoulos, GD ;
DePinho, RA .
NATURE, 1999, 400 (6743) :468-472
[28]   Teratogen-mediated inhibition of target tissue response to Shh signaling [J].
Cooper, MK ;
Porter, JA ;
Young, KE ;
Beachy, PA .
SCIENCE, 1998, 280 (5369) :1603-1607
[29]   A mouse model for medulloblastoma and basal cell nevus syndrome [J].
Corcoran, RB ;
Scott, MP .
JOURNAL OF NEURO-ONCOLOGY, 2001, 53 (03) :307-318
[30]  
Dahmane N, 1999, DEVELOPMENT, V126, P3089
12345678910