Genetics and pancreatic disease

被引：4
作者：
Schneider, A
Pfützer, R
Whitcomb, DC
机构：
[1] Heidelberg Univ, Dept Gastroenterol Hepatol & Infect Dis, D-6800 Mannheim, Germany
[2] Vet Adm Pittsburgh Hlth Care Syst, Pittsburgh, PA USA
[3] Univ Pittsburgh, Dept Med, Pittsburgh, PA USA
来源：
CURRENT OPINION IN GASTROENTEROLOGY | 2002年 / 18卷 / 05期
关键词：
D O I：
10.1097/00001574-200209000-00004
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
The recognition that variations in the DNA sequence of key genes predispose individuals to acute pancreatitis, chronic pancreatitis, and pancreatic cancer represents one of the greatest breakthroughs in pancreas research. This review highlights recent progress in understanding mutations in the cationic trypsinogen gene, the pancreatic secretory trypsin inhibitor gene, and the cystic fibrosis transmembrane conductance regulator gene with respect to pancreatitis. It also notes progress in the use of microarray technology, classification of chronic pancreatitis, and predisposition to pancreatic cancer. (C) 2002 Lippincott Williams Wilkins, Inc.
引用
收藏
页码：545 / 551
页数：7
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