Ideal cardiovascular health in childhood-Longitudinal associations with cardiac structure and function: The Special Turku Coronary Risk Factor Intervention Project (STRIP) and the Cardiovascular Risk in Young Finns Study (YFS)

被引：25

作者：

Laitinen, Tomi T. ^{[1
,2
]}

Ruohonen, Saku ^{[1
]}

Juonala, Markus ^{[1
,3
,4
]}

Magnussen, Costan G. ^{[1
,5
]}

Mikkila, Vera ^{[1
,6
]}

Mikola, Hanna ^{[1
]}

Hutri-Kahonen, Nina ^{[7
,8
]}

Laitinen, Tomi ^{[9
,10
]}

Tossavainen, Paivi ^{[11
]}

Jokinen, Eero ^{[12
]}

Niinikoski, Harri ^{[13
,14
]}

Jula, Antti ^{[15
]}

Viikari, Jorma S. A. ^{[3
,4
]}

Ronnemaa, Tapani ^{[3
,4
]}

Raitakari, Olli T. ^{[1
,14
,16
]}

Pahkala, Katja ^{[1
,2
]}

机构：

[1] Univ Turku, Res Ctr Appl & Prevent Cardiovasc Med, Kiinamyllynkatu 10, FIN-20520 Turku, Finland

[2] Univ Turku, Dept Phys Act & Hlth, Sports & Exercise Med Unit, Paavo Nurmi Ctr, Turku, Finland

[3] Univ Turku, Dept Med, Turku, Finland

[4] Turku Univ Hosp, Div Med, Turku, Finland

[5] Univ Tasmania, Menzies Inst Med Res, Hobart, Tas, Australia

[6] Univ Helsinki, Dept Food & Environm Sci, Helsinki, Finland

[7] Univ Tampere, Dept Pediat, Tampere, Finland

[8] Tampere Univ Hosp, Tampere, Finland

[9] Kuopio Univ Hosp, Dept Clin Physiol & Nucl Med, Kuopio, Finland

[10] Univ Eastern Finland, Kuopio, Finland

[11] Univ Oulu, Dept Pediat, Oulu, Finland

[12] Univ Helsinki, Hosp Children & Adolescents, Dept Pediat Cardiol, Helsinki, Finland

[13] Univ Turku, Dept Pediat & Adolescent Med, Turku, Finland

[14] Turku Univ Hosp, Turku, Finland

[15] Inst Hlth & Welf, Dept Chron Dis Prevent, Turku, Finland

[16] Univ Turku, Dept Clin Physiol & Nucl Med, Turku, Finland

来源：

INTERNATIONAL JOURNAL OF CARDIOLOGY | 2017年 / 230卷

基金：

芬兰科学院;

关键词：

Left ventricular mass; Risk factors; Diastolic dysfunction; Echocardiography; Cardiovascular disease prevention; LEFT-VENTRICULAR MASS; LIFE-STYLE INTERVENTION; INTIMA-MEDIA THICKNESS; INFANCY-ONSET DIETARY; MYOCARDIAL-INFARCTION; EUROPEAN-ASSOCIATION; METABOLIC SYNDROME; AMERICAN-SOCIETY; EARLY ADULTHOOD; COHORT PROFILE;

D O I：

10.1016/j.ijcard.2016.12.117

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Background: Ideal cardiovascular health (CVH), defined by the American Heart Association, is associated with incident cardiovascular disease in adults. However, association of the ideal CVH in childhood with current and future cardiac structure and function has not been studied. Methods and results: The sample comprised 827 children participating in the longitudinal Special Turku Coronary Risk Factor Intervention Project (STRIP) and The Cardiovascular Risk in Young Finns Study (YFS). In STRIP, complete data on the seven ideal CVH metrics and left ventricular (LV) mass measured with echocardiography were available at the age of 15 (n= 321), 17 (n= 309) and 19 (n= 283) years. In YFS, the cohort comprised children aged 12-18 years (n = 506) with complete ideal CVH metrics data from childhood and 25 years later in adulthood, and echocardiography performed in adulthood. In STRIP, ideal CVH score was inversely associated with LV mass during childhood (P = 0.036). In YFS, childhood ideal CVH score was inversely associated with LV mass, LV end-diastolic volume, E/e' ratio, and left atrium end-systolic volume in adulthood (all P < 0.01). In addition, improvement of the ideal CVH score between childhood and adulthood was inversely associated with LV mass, LV end-diastolic volume, E/e' ratio, and left atrium end-systolic volume (all P <= 0.03). Conclusions: Childhood ideal CVH score has a long-lasting effect on cardiac structure and function, and the association is evident already in childhood. Our findings support targeting the ideal CVHmetrics as part of primordial prevention of cardiovascular diseases. (C) 2016 Elsevier Ireland Ltd. All rights reserved.

引用

页码：304 / 309

页数：6

共 28 条

[1] Prospective Relationship of Change in Ideal Cardiovascular Health Status and Arterial Stiffness: The Cardiovascular Risk in Young Finns Study [J].