Identification of Ferroptosis-Related Genes in Schizophrenia Based on Bioinformatic Analysis

被引：21

作者：

Feng, Shunkang ^{[1
,2
]}

Chen, Jun ^{[3
,4
,5
,6
]}

Qu, Chunhui ^{[2
]}

Yang, Lu ^{[3
,4
]}

Wu, Xiaohui ^{[3
,4
]}

Wang, Shuo ^{[3
,4
]}

Yang, Tao ^{[3
,4
]}

Liu, Hongmei ^{[3
,4
]}

Fang, Yiru ^{[3
,4
,5
,6
]}

Sun, Ping ^{[2
,3
,4
]}

机构：

[1] Qingdao Univ, Med Coll, Qingdao 266071, Peoples R China

[2] Qingdao Mental Hlth Ctr, Qingdao 266034, Peoples R China

[3] Shanghai Jiao Tong Univ, Clin Res Ctr, Sch Med, Shanghai 200030, Peoples R China

[4] Shanghai Jiao Tong Univ, Shanghai Mental Hlth Ctr, Div Mood Disorders, Sch Med, Shanghai 200030, Peoples R China

[5] CAS Ctr Excellence Brain Sci & Intelligence Techno, Shanghai 200031, Peoples R China

[6] Shanghai Key Lab Psychot Disorders, Shanghai 201108, Peoples R China

来源：

GENES | 2022年 / 13卷 / 11期

关键词：

ferroptosis; schizophrenia; GEO; bioinformatic; EXPRESSION; TP53;

D O I：

10.3390/genes13112168

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The purpose of this study is to explore the correlation between ferroptosis-related genes and schizophrenia in order to explore the new direction of diagnosis and treatment of schizophrenia. We screened the datasets related to schizophrenia from the Gene Expression Comprehensive Database (GEO) and obtained ferroptosis-related genes from the FerrDB database. Bioinformatics methods were used to analyze differentially expressed genes (DEGs) and genes associated with ferroptosis-related between schizophrenia patients and healthy controls. On this basis, the hub genes were finally screened by enrichment analysis and PPI interaction analysis. Hub genes associated with ferroptosis were validated using other schizophrenia datasets in the GEO database. Finally, the hub gene-microRNA (miRNA), gene-transcription factor interaction network was constructed, and three ferroptosis-related hub genes (TP53, VEGFA and PTGS2) were screened. The validation results of these three genes in other datasets also support this conclusion. A miRNA: hsa-mir-16-5p was found to be related to the three hub genes, and pPHF8, SAP30 and lKDM5B were identified as common regulators of the three hub genes. Our results indicate that TP53, VEGFA and PTGS2 are significantly associated with schizophrenia, and may be ferroptosis-related markers of the disease.

引用

页数：12

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