The Mouse Genome Database: integration of and access to knowledge about the laboratory mouse

被引：163

作者：

Blake, Judith A. ^{[1
]}

Bult, Carol J. ^{[1
]}

Eppig, Janan T. ^{[1
]}

Kadin, James A. ^{[1
]}

Richardson, Joel E. ^{[1
]}

机构：

[1] Jackson Lab, Bar Harbor, ME 04609 USA

来源：

NUCLEIC ACIDS RESEARCH | 2014年 / 42卷 / D1期

关键词：

ONTOLOGY; MGD;

D O I：

10.1093/nar/gkt1225

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The Mouse Genome Database (MGD) (http://www.informatics.jax.org) is the community model organism database resource for the laboratory mouse, a premier animal model for the study of genetic and genomic systems relevant to human biology and disease. MGD maintains a comprehensive catalog of genes, functional RNAs and other genome features as well as heritable phenotypes and quantitative trait loci. The genome feature catalog is generated by the integration of computational and manual genome annotations generated by NCBI, Ensembl and Vega/HAVANA. MGD curates and maintains the comprehensive listing of functional annotations for mouse genes using the Gene Ontology, and MGD curates and integrates comprehensive phenotype annotations including associations of mouse models with human diseases. Recent improvements include integration of the latest mouse genome build (GRCm38), improved access to comparative and functional annotations for mouse genes with expanded representation of comparative vertebrate genomes and new loads of phenotype data from high-throughput phenotyping projects. All MGD resources are freely available to the research community.

引用

页码：D810 / D817

页数：8

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