Imidazopyridine-fused [1,3] -diazepinones: Synthesis and antiproliferative activity

被引：45
作者：
Gallud, Audrey [1 ,2 ]
Vaillant, Ophelie [1 ,2 ]
Maillard, Ludovic T. [1 ,2 ]
Arama, Dominique P. [1 ,2 ]
Dubois, Joelle [3 ]
Maynadier, Marie [1 ,2 ]
Lisowski, Vincent [1 ,2 ]
Garcia, Marcel [1 ,2 ]
Martinez, Jean [1 ,2 ]
Masurier, Nicolas [1 ,2 ]
机构：
[1] Univ Montpellier I, CNRS, UMR 5247, Inst Biomol Max Mousseron, F-34093 Montpellier 5, France
[2] Univ Montpellier 2, UFR Sci Pharmaceut & Biol, F-34093 Montpellier 5, France
[3] CNRS, Ctr Rech Gif, UPR 2301, Inst Chim Subst Nat, F-91198 Gif Sur Yvette, France
来源：
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 2014年 / 75卷
关键词：
Imidazo[1,2-a]pyridine; Polyfused heterocycles; Diazepinones; Antitumor activity; HGK inhibitors; GLYCOGEN-SYNTHASE KINASE-3-BETA; DEPENDENT KINASE INHIBITOR; ERM PROTEINS; PAULLONES; SCREEN; CANCER; HGK; EXPRESSION; DISCOVERY; INVASION;
D O I：
10.1016/j.ejmech.2014.01.044
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
A series of 15 pyrido-imidazo-1,3-diazepin-5-ones and pyrido-1,3-diazepine-2,5-diones were synthesized and their anticancer activities were evaluated. Among tested compounds on a cell lines panel, compound 6a presents the best growth inhibition activity on 21 cell lines with a cytotoxic effect on MDA-MB-435 melanoma cells. This compound led to deep cell morphological changes and revealed to be an inhibitor of the Hepatocyte progenitor kinase-like kinase (HGK), which is known to be implicated in the migration, adhesion and invasion of various tumor cells. (C) 2014 Elsevier Masson SAS. All rights reserved.
引用
收藏
页码：382 / 390
页数：9
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