Titers of Herpes Simplex Virus Type 1 Antibodies Positively Correlate with Grey Matter Volumes in Alzheimer's Disease

被引：62

作者：

Mancuso, Roberta ^{[1
]}

Baglio, Francesca ^{[1
]}

Cabinio, Monia ^{[1
,2
]}

Calabrese, Elena ^{[1
]}

Hernis, Ambra ^{[1
]}

Nemni, Raffaello ^{[1
,2
]}

Clerici, Mario ^{[1
,2
]}

机构：

[1] Don Carlo Gnocchi Fdn, IRCCS, Milan, Italy

[2] Univ Milan, Dept Physiopathol & Transplantat, Milan, Italy

来源：

JOURNAL OF ALZHEIMERS DISEASE | 2014年 / 38卷 / 04期

关键词：

Alzheimer's disease; HSV-1; humoral immunity; magnetic resonance imaging; BLOOD-BRAIN-BARRIER; INFECTIOUS AGENTS; DEMENTIA; PERMEABILITY; ENCEPHALITIS; DIAGNOSIS; RISK;

D O I：

10.3233/JAD-130977

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

HSV-1 infection of the central nervous system targets the same brain regions most affected in Alzheimer's disease (AD) and could play a pathogenic role in AD. HSV-1 serum IgG titers were analyzed in patients with mild AD(n = 83) and healthy controls (HC, n = 51); results were correlated with cortical grey matter (GM) volumes as analyzed by MRI. Seroprevalence and antibody (Ab) titers were comparable between AD and HC; elevated Ab titers (>75th percentile) were nevertheless significantly more frequent in AD and were positively correlated with cortical bilateral temporal and orbitofrontal GM volumes. HSV-1-specific-Ab could possibly play a protective role in the early stages of AD.

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收藏

页码：741 / 745

页数：5

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