Efficacy of Fecal Microbiota Transplantation in 2 Children With Recurrent Clostridium difficile Infection and Its Impact on Their Growth and Gut Microbiome

被引：32

作者：

Walia, Ritu ^{[1
]}

Garg, Shashank ^{[2
]}

Song, Yang ^{[3
]}

Girotra, Mohit ^{[2
]}

Cuffari, Carmen ^{[4
]}

Fricke, Wolfgang Florian ^{[3
]}

Dutta, Sudhir K. ^{[5
]}

机构：

[1] W Virginia Univ, Div Pediat Gastroenterol, Dept Pediat, Charleston, WV USA

[2] Sinai Hosp, Div Gastroenterol, Dept Med, Program Internal Med, Baltimore, MD 21215 USA

[3] Univ Maryland, Sch Med, Inst Genome Sci, Baltimore, MD 21201 USA

[4] Johns Hopkins Univ, Dept Pediat, Div Pediat Gastroenterol, Baltimore, MD 21218 USA

[5] Sinai Hosp, Dept Med, Div Gastroenterol, Baltimore, MD 21215 USA

来源：

JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION | 2014年 / 59卷 / 05期

关键词：

Clostridium difficile infection; fecal microbiota transplantation; growth; recurrent; INFANTS;

D O I：

10.1097/MPG.0000000000000495

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Fecal microbiota transplantation (FMT) is recognized as an alternative therapeutic modality for recurrent Clostridium difficile infection (RCDI); however, data on its efficacy in children are lacking, including its effect on their growth and fecal microbiota. We report on 2 young children (<3 years old) who failed available therapeutics for RCDI, but responded remarkably well to FMT. Besides resolution of clinical features of C difficile infection (CDI), FMT administration led to marked improvement in their growth, along with increased microbiota diversity, especially proportion of Bacteroides. Our 2 cases illustrate the efficacy of FMT in children with RCDI and its positive effect on their growth and gut microbiota.

引用

页码：565 / 570

页数：6

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