Formulation design and evaluation of aceclofenac nanogel for topical application

被引：30
作者：
Alam, Md. Shoaib [1 ,3 ]
Algahtani, Mohammed S. [2 ]
Ahmad, Javed [2 ]
Kohli, Kanchan [3 ]
Shafiq-un-Nabi, Sheikh [1 ]
Warsi, Musarrat Husain [4 ]
Ahmad, Mohammad Zaki [2 ]
机构：
[1] Jamjoom Pharmaceut, Res & Dev, Jeddah, Saudi Arabia
[2] Najran Univ, Dept Pharmaceut, Coll Pharm, Najran, Saudi Arabia
[3] Jamia Hamdard, Sch Pharmaceut Educ & Res, Dept Pharmaceut, New Delhi, India
[4] Taif Univ, Coll Pharm, Dept Pharmaceut & Ind Pharm, Taif Al Haweiah, Saudi Arabia
来源：
THERAPEUTIC DELIVERY | 2020年 / 11卷 / 12期
关键词：
aceclofenac; carbopol; 940; high-pressure homogenization; nanoemulsion; nanoemulgel; topical application; HIGH-PRESSURE HOMOGENIZATION; LIFE SETTING TRIALS; DRUG-DELIVERY; IN-VITRO; OSTEOARTHRITIS EVIDENCE; TRANSDERMAL DELIVERY; NANOEMULSION; SYSTEMS; MANAGEMENT; NSAIDS;
D O I：
10.4155/tde-2020-0076
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Aim: The current study aimed to explore the feasibility of the nanoemulgel for the topical delivery of aceclofenac. Materials & methods: Solubility of drugs in the formulation systems was determined and aceclofenac nanoemulsion (NE) was prepared by high-pressure homogenization technique. Carbopol 940 was added as a gelling agent. Results & conclusion: The composition of optimized NE consist of labrafil along with triacetin as oil, tween 80 and cremophor EL in combination as a surfactant and transcutol HP along with PEG 400 and ethanol as cosurfactant. The droplet size of the NE was 141.1 +/- 3.65 nm, with low polydispersity index and negative zeta potential. The aceclofenac-nanoemulgel was developed using carbopol 940 and exhibited excellent permeation in comparison to the marketed sample.
引用
收藏
页码：767 / 778
页数：12
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