Non-coding RNAs in skin cancers:Biological roles and molecular mechanisms

被引：11
作者：
Liu, Fei [1 ]
Li, Shenglong [1 ]
机构：
[1] China Med Univ, Liaoning Canc Hosp & Inst, Canc Hosp, Dept Bone & Soft Tissue Tumor Surg, Shenyang, Peoples R China
来源：
FRONTIERS IN PHARMACOLOGY | 2022年 / 13卷
关键词：
skin cancers; non-coding RNA; malignant progression; molecular biology; metastasis; SQUAMOUS-CELL CARCINOMA; CIRCULAR RNA; CUTANEOUS MELANOMA; DOWN-REGULATION; TUMOR-SUPPRESSOR; CISPLATIN RESISTANCE; MALIGNANT-MELANOMA; GENE-EXPRESSION; CYCLIN D1; PROGRESSION;
D O I：
10.3389/fphar.2022.934396
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Cutaneous malignancies, including basal cell carcinoma, cutaneous squamous cell carcinoma, and cutaneous melanoma, are common human tumors. The incidence of cutaneous malignancies is increasing worldwide, and the leading cause of death is malignant invasion and metastasis. The molecular biology of oncogenes has drawn researchers' attention because of the potential for targeted therapies. Noncoding RNAs, including microRNAs, long noncoding RNAs, and circular RNAs, have been studied extensively in recent years. This review summarizes the aspects of noncoding RNAs related to the metastasis mechanism of skin malignancies. Continuous research may facilitate the identification of new therapeutic targets and help elucidate the mechanism of tumor metastasis, thus providing new opportunities to improve the survival rate of patients with skin malignancies.
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页数：18
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