A pseudotype vesicular stomatitis virus containing Hantaan virus envelope glycoproteins G1 and G2 as an alternative to hantavirus vaccine in mice

被引：25

作者：

Lee, BH ^{[1
]}

Yoshimatsu, K ^{[1
]}

Araki, K ^{[1
]}

Okumura, M ^{[1
]}

Nakamura, I ^{[1
]}

Arikawa, J ^{[1
]}

机构：

[1] Hokkaido Univ, Grad Sch Med, Inst Anim Expt, Kita Ku, Sapporo, Hokkaido 0608638, Japan

来源：

VACCINE | 2006年 / 24卷 / 15期

关键词：

envelope; hantavirus; pseudotype;

D O I：

10.1016/j.vaccine.2005.12.040

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We examined whether a vesicular stomatitis virus (VSV) pseudotype bearing the hantavirus envelope glycoproteins (GPs) G1 and G2 (VSV Delta G*HTN) could be used as a safe and effective alternative to native hantavirus. Mice were immunized with purified particles of VSV Delta G*HTN. After the second immunization, all mice produced anti-GP antibody as detected in ELISA and a neutralization test. After the third immunization, the mice were challenged with Hantaan virus. Neither anti-NP antibody production nor Hantaan virus-specific CD8 T-cell reactions were detected in these mice. The present study demonstrated the potential of using a pseudotype VSV system as a tool for developing a hantavirus vaccine. (c) 2005 Elsevier Ltd. All rights reserved.

引用

页码：2928 / 2934

页数：7

共 32 条

[1] Hantavirus-specific CD8+-T-cell responses in newborn mice persistently infected with Hantaan virus [J].

Araki, K ;

Yoshimatsu, K ;

Lee, BH ;

Kariwa, H ;

Takashima, I ;

Arikawa, J .

JOURNAL OF VIROLOGY, 2003, 77 (15) :8408-8417

[2] Truncated hantavirus nucleocapsid proteins for serotyping Hantaan, Seoul, and Dobrava hantavirus infections [J].

Araki, K ;

Yoshimatsu, K ;

Ogino, M ;

Ebihara, H ;

Lundkvist, Å ;

Kariwa, H ;

Takashima, I ;

Arikawa, J .

JOURNAL OF CLINICAL MICROBIOLOGY, 2001, 39 (07) :2397-2404

[3] CHARACTERIZATION OF HANTAAN VIRUS ENVELOPE GLYCOPROTEIN ANTIGENIC DETERMINANTS DEFINED BY MONOCLONAL-ANTIBODIES [J].

ARIKAWA, J ;

SCHMALJOHN, AL ;

DALRYMPLE, JM ;

SCHMALJOHN, CS .

JOURNAL OF GENERAL VIROLOGY, 1989, 70 :615-624

[4] CROSS-REACTIVE IMMUNITY AMONG DIFFERENT SEROTYPES OF VIRUS CAUSING HEMORRHAGIC-FEVER WITH RENAL SYNDROME [J].

ASADA, H ;

BALACHANDRA, K ;

TAMURA, M ;

KONDO, K ;

YAMANISHI, K .

JOURNAL OF GENERAL VIROLOGY, 1989, 70 :819-825

[5] Hepatitis C virus envelope glycoproteins and potential for vaccine development [J].

Beyene, A ;

Basu, A ;

Meyer, K ;

Ray, R .

VOX SANGUINIS, 2002, 83 :27-32

[6] CRYSTALLIZATION OF THE FAB FROM A HUMAN MONOCLONAL-ANTIBODY AGAINST GP-41 OF HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-I [J].

CASALE, E ;

WENISCH, E ;

HE, XM ;

RIGHETTI, PG ;

SNYDER, RS ;

JUNGBAUER, A ;

TAUER, C ;

RUKER, F ;

CARTER, DC .

JOURNAL OF MOLECULAR BIOLOGY, 1990, 216 (03) :511-512

[7] TECHNIQUES FOR HEMAGGLUTINATION AND HEMAGGLUTINATION-INHIBITION WITH ARTHROPOD-BORNE VIRUSES [J].

CLARKE, DH ;

CASALS, J .

AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE, 1958, 7 (05) :561-573

[8]

*HANT VACC DEP, 1996, B WORLD HEALTH ORGAN, V74, P336

[9] ANTI-HBS RESPONSES TO VACCINATION WITH A HUMAN HEPATITIS-B VACCINE MADE BY RECOMBINANT-DNA TECHNOLOGY IN YEAST [J].

HOLLINGER, FB ;

TROISI, CL ;

PEPE, PE .

JOURNAL OF INFECTIOUS DISEASES, 1986, 153 (01) :156-159

[10] DNA vaccination with Hantavirus M segment elicits neutralizing antibodies and protects against Seoul virus infection [J].

Hooper, JW ;

Kamrud, KI ;

Elgh, F ;

Custer, D ;

Schmaljohn, CS .

VIROLOGY, 1999, 255 (02) :269-278

← 1 2 3 4 →