Antimicrobial properties of milk: Dependence on presence of xanthine oxidase and nitrite

被引：93
|
作者：
Hancock, JT
Salisbury, V
Ovejero-Boglione, MC
Cherry, R
Hoare, C
Eisenthal, R
Harrison, R
机构：
[1] Univ W England, Ctr Biomed Res, Bristol BS16 1QY, Avon, England
[2] Univ Bath, Dept Biol & Biochem, Bath BA2 7AY, Avon, England
来源：
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2002年 / 46卷 / 10期
基金：
英国惠康基金;
关键词：
D O I：
10.1128/AAC.46.10.3308-3310.2002
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Human and bovine milk inhibited the metabolic activity of Escherichia coli, as shown by luminescence monitoring of constructs expressing the luxCDABE genes. Inhibition was dependent on both xanthine oxidase (XO) activity and on the presence of nitrite, implying that XO-generated nitric oxide functions as an antibacterial agent.
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页码：3308 / 3310
页数：3
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