Antimicrobial properties of milk: Dependence on presence of xanthine oxidase and nitrite

被引：93
作者：
Hancock, JT
Salisbury, V
Ovejero-Boglione, MC
Cherry, R
Hoare, C
Eisenthal, R
Harrison, R
机构：
[1] Univ W England, Ctr Biomed Res, Bristol BS16 1QY, Avon, England
[2] Univ Bath, Dept Biol & Biochem, Bath BA2 7AY, Avon, England
来源：
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2002年 / 46卷 / 10期
基金：
英国惠康基金;
关键词：
D O I：
10.1128/AAC.46.10.3308-3310.2002
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Human and bovine milk inhibited the metabolic activity of Escherichia coli, as shown by luminescence monitoring of constructs expressing the luxCDABE genes. Inhibition was dependent on both xanthine oxidase (XO) activity and on the presence of nitrite, implying that XO-generated nitric oxide functions as an antibacterial agent.
引用
收藏
页码：3308 / 3310
页数：3
相关论文
共 25 条
[1]   PURIFICATION AND PARTIAL CHARACTERIZATION OF XANTHINE-OXIDASE FROM HUMAN-MILK [J].
ABADEH, S ;
KILLACKY, J ;
BENBOUBETRA, M ;
HARRISON, R .
BIOCHIMICA ET BIOPHYSICA ACTA, 1992, 1117 (01) :25-32
[2]   BINDING OF HUMAN XANTHINE-OXIDASE TO SULFATED GLYCOSAMINOGLYCANS ON THE ENDOTHELIAL-CELL SURFACE [J].
ADACHI, T ;
FUKUSHIMA, T ;
USAMI, Y ;
HIRANO, K .
BIOCHEMICAL JOURNAL, 1993, 289 :523-527
[3]  
[Anonymous], 1980, ADV BACTERIAL GENET
[4]   RELATION BETWEEN INFANT-FEEDING AND INFECTIONS DURING THE FIRST 6 MONTHS OF LIFE [J].
BEAUDRY, M ;
DUFOUR, R ;
MARCOUX, S .
JOURNAL OF PEDIATRICS, 1995, 126 (02) :191-197
[5]   Bioluminescence-based assays for detection and characterization of bacteria and chemicals in clinical laboratories [J].
Billard, P ;
DuBow, MS .
CLINICAL BIOCHEMISTRY, 1998, 31 (01) :1-14
[6]   MOLECULAR ACTIVATION DEACTIVATION OF XANTHINE-OXIDASE IN HUMAN-MILK [J].
BROWN, AM ;
BENBOUBETRA, M ;
ELLISON, M ;
POWELL, D ;
RECKLESS, JD ;
HARRISON, R .
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, 1995, 1245 (02) :248-254
[7]   THE COMPARATIVE TOXICITY OF NITRIC-OXIDE AND PEROXYNITRITE TO ESCHERICHIA-COLI [J].
BRUNELLI, L ;
CROW, JP ;
BECKMAN, JS .
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 1995, 316 (01) :327-334
[8]  
Cole J, 1996, FEMS MICROBIOL LETT, V136, P1
[9]   NARK ENHANCES NITRATE UPTAKE AND NITRITE EXCRETION IN ESCHERICHIA-COLI [J].
DEMOSS, JA ;
HSU, PY .
JOURNAL OF BACTERIOLOGY, 1991, 173 (11) :3303-3310
[10]  
Gartner LM, 1997, PEDIATRICS, V100, P1035, DOI 10.1542/peds.100.6.1035
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