New insights into Chlamydia intracellular survival mechanisms

被引:76
作者
Cocchiaro, Jordan L. [1 ]
Valdivia, Raphael H. [1 ,2 ]
机构
[1] Duke Univ, Med Ctr, Dept Mol Genet & Microbiol, Durham, NC 27710 USA
[2] Duke Univ, Med Ctr, Ctr Microbial Pathogenesis, Durham, NC USA
基金
英国惠康基金; 美国国家卫生研究院;
关键词
TRACHOMATIS-INFECTED CELLS; OUTER-MEMBRANE PROTEIN; NF-KAPPA-B; EARLY-CYCLE DEVELOPMENT; DEVELOPMENTAL CYCLE; INCLUSION MEMBRANE; RAB GTPASES; PROAPOPTOTIC PROTEINS; MULTIVESICULAR BODIES; EPITHELIAL-CELLS;
D O I
10.1111/j.1462-5822.2009.01364.x
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
P>Chlamydia sp. are responsible for a wide range of diseases of significant clinical and public health importance. In this review, we highlight how recent cellular and functional genomic approaches have significantly increased our knowledge of the pathogenic mechanisms used by these genetically intractable bacteria. As the extensive repertoire of chlamydial proteins that are translocated into the mammalian host is identified and characterized, a molecular understanding of how Chlamydiae co-opt host cellular functions and block innate immune pathways is beginning to emerge.
引用
收藏
页码:1571 / 1578
页数:8
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