CSF tau protein phosphorylated at threonine 231 correlates with cognitive decline in MCI subjects

被引：201
作者：
Buerger, K
Teipel, SJ
Zinkowski, R
Blennow, K
Arai, H
Engel, R
Hofmann-Kiefer, K
McCulloch, C
Ptok, U
Heun, R
Andreasen, N
DeBernardis, J
Kerkman, D
Moeller, HJ
Davies, P
Hampel, H
机构：
[1] Mol Geriatr Corp, Vernon Hills, IL 60061 USA
[2] Univ Munich, Dementia Res Sect, Munich, Germany
[3] Univ Munich, Memory Clin, Munich, Germany
[4] Univ Munich, Alzheimer Mem Ctr, Dept Psychiat, Munich, Germany
[5] Univ Munich, Dept Anesthesiol, Munich, Germany
[6] Univ Gothenburg, Sahlgrens Univ Hosp, Dept Clin Neurosci, Unit Neurochem, Molndal, Sweden
[7] Tohoku Univ, Sch Med, Dept Geriatr Med, Sendai, Miyagi 980, Japan
[8] Univ Bonn, Dept Psychiat, D-5300 Bonn, Germany
[9] Pitea River Valley Hosp, Dept Rehabil, Pitea, Sweden
[10] Albert Einstein Coll Med, Dept Pathol, Bronx, NY 10467 USA
来源：
NEUROLOGY | 2002年 / 59卷 / 04期
关键词：
D O I：
10.1212/WNL.59.4.627
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
In this longitudinal study of 77 patients with mild cognitive impairment (MCI), the authors analyzed whether levels of tau protein phosphorylated at threonine 231 (p-tau(231)) in CSF correlate with progression of cognitive decline. High CSF p-tau(231) levels at baseline, but not total tau protein levels, correlated with cognitive decline and conversion from MCI to AD. Independently, old age and APOE-epsilon4 carrier status were predictive as well. Our data indicate that an increased p-tau(231) level is a potential risk factor for cognitive decline in patients with MCI.
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收藏
页码：627 / 629
页数：3
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