Dynamics of Human Immunodeficiency Virus-1 Genetic Diversification During Acute Infection

被引：1

作者：

Song, Hongshuo ^{[1
,2
,3
]}

Bose, Meera ^{[1
,2
]}

Pinyakorn, Suteeraporn ^{[1
,2
]}

Sanders-Buell, Eric ^{[1
,2
]}

O'Sullivan, Anne Marie ^{[1
,2
]}

Silas, Daniel ^{[1
,2
]}

Trichavaroj, Rapee ^{[4
]}

Nuntapinit, Bessara ^{[4
]}

Pham, Phuc T. ^{[1
,2
]}

Akapirat, Siriwat ^{[4
]}

Kroon, Eugene ^{[5
]}

de Souza, Mark ^{[1
,2
,5
]}

Gramzinski, Robert ^{[1
,2
]}

Michael, Nelson L. ^{[1
]}

Robb, Merlin L. ^{[1
,2
]}

Vasan, Sandhya ^{[1
,2
]}

Tovanabutra, Sodsai ^{[1
,2
]}

Ananworanich, Jintanat ^{[1
,2
,5
,6
,7
]}

机构：

[1] Walter Reed Army Inst Res, US Mil HIV Res Program, Silver Spring, MD USA

[2] Henry M Jackson Fdn Adv Mil Med Inc, Bethesda, MD USA

[3] Univ Maryland, Inst Human Virol, Sch Med, 725 W Lombard St,Room N248, Baltimore, MD 21201 USA

[4] Armed Forces Res Inst Med Sci, Bangkok, Thailand

[5] Thai Red Cross Res Ctr, SEARCH, Bangkok, Thailand

[6] Univ Amsterdam, Amsterdam Univ Med Ctr, Dept Global Hlth, Amsterdam, Netherlands

[7] Amsterdam Inst Global Hlth & Dev, Amsterdam, Netherlands

来源：

OPEN FORUM INFECTIOUS DISEASES | 2020年 / 7卷 / 10期

关键词：

acute HIV infection; Fiebig stage; genetic diversity; HIV; HIV-1; FORMS; ASIA;

D O I：

10.1093/ofid/ofaa429

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We analyzed human immunodeficiency virus envelope diversity in 98 acute infections. The within-host genetic diversity, divergence from transmitted/founder (T/F) strain, and the observed frequency of multiple TIP infections increased with Fiebig stage. These data identify rapid viral dynamics during acute infection with implications for clinical trials conducted in this setting.

引用

页码：1 / 4

页数：4

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