Immunocytokines: a novel class of products for the treatment of chronic inflammation and autoimmune conditions

被引：48

作者：

Bootz, Franziska ^{[1
]}

Neri, Dario ^{[1
]}

机构：

[1] Swiss Fed Inst Technol, Swiss Fed Inst Technol, Dept Chem & Appl Biosci, Vladimir Prelog Weg 1-5-10, CH-8093 Zurich, Switzerland

来源：

DRUG DISCOVERY TODAY | 2016年 / 21卷 / 01期

基金：

瑞士国家科学基金会;

关键词：

COLLAGEN-INDUCED ARTHRITIS; TUMOR-TARGETING PROPERTIES; QUALITY-OF-LIFE; ANTIBODY-MEDIATED DELIVERY; CYTOKINE FUSION PROTEINS; NECROSIS-FACTOR-ALPHA; SPLICED EDA DOMAIN; IB CLINICAL-TRIAL; PHASE-II TRIAL; DOUBLE-BLIND;

D O I：

10.1016/j.drudis.2015.10.012

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Antibody-cytokine fusion proteins, often referred to as immunocytokines, represent a novel class of biopharmaceutical agents that combine the disease-homing activity of certain antibodies with the immunomodulatory properties of cytokine payloads. Originally, immunocytokines were mainly developed for cancer therapy applications. More recently, however, the use of anti-inflammatory cytokines for the treatment of chronic inflammatory conditions and to treat autoimmune diseases has been considered. This review analyzes basic principles in the design of immunocytokines and describes the most advanced products in preclinical and clinical development.

引用

收藏

页码：180 / 189

页数：10

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