The Rotterdam Scan Study: design update 2016 and main findings

被引：166
作者：
Ikram, M. Arfan [1 ,2 ,3 ]
van der Lugt, Aad [2 ]
Niessen, Wiro J. [4 ,5 ]
Koudstaal, Peter J. [3 ]
Krestin, Gabriel P. [2 ]
Hofman, Albert [1 ]
Bos, Daniel [1 ,2 ]
Vernooij, Meike W. [1 ,2 ]
机构：
[1] Erasmus MC Univ Med Ctr, Dept Epidemiol, NL-3000 CA Rotterdam, Netherlands
[2] Erasmus MC Univ Med Ctr, Dept Radiol, NL-3000 CA Rotterdam, Netherlands
[3] Erasmus MC Univ Med Ctr, Dept Neurol, NL-3000 CA Rotterdam, Netherlands
[4] Erasmus MC Univ Med Ctr, Biomed Imaging Grp Rotterdam, NL-3000 CA Rotterdam, Netherlands
[5] Delft Univ Technol, Fac Sci Appl, Delft, Netherlands
来源：
EUROPEAN JOURNAL OF EPIDEMIOLOGY | 2015年 / 30卷 / 12期
关键词：
Epidemiology; Population-based; Risk factors; Neuroimaging; Cohort study; Dementia; Stroke; Alzheimer's disease; Microbleeds; White matter lesions; Infarcts; Cerebral blood flow; Diffusion tensor imaging; Genetics; CEREBRAL-BLOOD-FLOW; WHITE-MATTER LESIONS; SMALL-VESSEL DISEASE; INDEPENDENT COMPONENT ANALYSIS; GENERAL ELDERLY POPULATION; BRAIN-TISSUE SEGMENTATION; GENOME-WIDE ASSOCIATION; COGNITIVE FUNCTION; RISK-FACTORS; PARKINSONS-DISEASE;
D O I：
10.1007/s10654-015-0105-7
中图分类号：
R1 [预防医学、卫生学];
学科分类号：
1004 ; 120402 ;
摘要：
Imaging plays an essential role in research on neurological diseases in the elderly. The Rotterdam Scan Study was initiated as part of the ongoing Rotterdam Study with the aim to elucidate the causes of neurological disease by performing imaging of the brain in a prospective population-based setting. Initially, in 1995 and 1999, random subsamples of participants from the Rotterdam Study underwent neuroimaging, whereas from 2005 onwards MRI has been implemented into the core protocol of the Rotterdam Study. In this paper, we discuss the background and rationale of the Rotterdam Scan Study. Moreover, we describe the imaging protocol, image post-processing techniques, and the main findings to date. Finally, we provide recommendations for future research, which will also be topics of investigation in the Rotterdam Scan Study.
引用
收藏
页码：1299 / 1315
页数：17
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