Synthesis and antimetastatic activity of metal complexes based on substituted pyridinecarboxylic acid amides and platinum tetrachloride

被引：7

作者：

Fedorov, B. S. ^{[1
]}

Fadeev, M. A. ^{[1
]}

Kozub, G. I. ^{[1
]}

Aldoshin, S. M. ^{[1
]}

Aliev, Z. G. ^{[1
]}

Atovmyan, L. O. ^{[1
]}

Konovalova, N. P. ^{[1
]}

Sashenkova, T. E. ^{[1
]}

Kondrat'eva, T. A. ^{[1
]}

Blokhina, S. V. ^{[1
]}

机构：

[1] Russian Acad Sci, Inst Problems Chem Phys, Chernogolovka 142432, Moscow Oblast, Russia

来源：

PHARMACEUTICAL CHEMISTRY JOURNAL | 2009年 / 43卷 / 03期

关键词：

platinum tetrachloride derivatives; dipotassium hexachloroplatinate; disodium hexachloroplatinate; metal complexes; substituted amides of nicotinic and isonicotinic acids; melanoma B-16; Lewis carcinoma of lung; toxicity; metastasis; PDCL2;

D O I：

10.1007/s11094-009-0256-5

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Previously unreported platinum tetrachloride derivatives have been synthesized via the interaction between dipotassium- and disodiumhexachloroplatinates with substituted amides of nicotinic and isonicotinic acid. The synthesized compounds exhibit low general toxicity and show high antimetastatic activity with respect to experimental melanoma B-16 and Lewis lung carcinoma strains.

引用

页码：134 / 138

页数：5

共 18 条

[1]

CHERNYAEV II, 1958, NEORG KHIM, P2025

[2] INVIVO EFFECTS OF CIS-DIAMMINEDICHLOROPLATINUM(II) AND TRANS-DIAMMINEDICHLOROPLATINUM(II) ON SV40 CHROMOSOMES - DIFFERENTIAL REPAIR, DNA PROTEIN CROSS-LINKING, AND INHIBITION OF REPLICATION [J].

CICCARELLI, RB ;

SOLOMON, MJ ;

VARSHAVSKY, A ;

LIPPARD, SJ .

BIOCHEMISTRY, 1985, 24 (26) :7533-7540

[3]

DEFEUDUS FV, 1989, DRUG TODAY, P115

[4] Synthesis and structures of complexes of N-2-nitroxyethylpicolinamide and 2-(2-pyridyl)-2-oxazoline with PdCl2 [J].

Fedorov, BS ;

Golovina, NI ;

Arakcheeva, VV ;

Fadeev, MA ;

Strukov, GV ;

Kedrov, VV ;

Shilov, GV ;

Atovmyan, LO .

RUSSIAN CHEMICAL BULLETIN, 1999, 48 (08) :1584-1586

[5] Synthesis and the crystal structures of N-(2-nitroxyethyl)isonicotinamide and its complexes with PdCl2 and PtCl2 as potential antitumor medicines [J].

Fedorov, BS ;

Golovina, NI ;

Fadeev, MA ;

Strukov, GV ;

Kedrov, VV ;

Shilov, GV ;

Boiko, GN ;

Atovmyan, LO .

RUSSIAN CHEMICAL BULLETIN, 2001, 50 (03) :520-524

[6]

FEDOROV BS, Patent No. 2147301

[7]

FEDOROV BS, Patent No. 2241713

[8]

FEDOROV BS, Patent No. 2245328

[9] NITRIC-OXIDE, NO, AN INTERCELLULAR MESSENGER [J].

GALLA, HJ .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION IN ENGLISH, 1993, 32 (03) :378-380

[10]

HARRAP KR, 1995, 5 INT C ANT CHEM PAR

← 1 2 →