Quantitative trait loci influencing hepatic copper in rats

被引：3
|
作者：
de Wolf, ID
Bonné, ACM
Fielmich-Bouman, XM
van Oost, BA
Beynen, AC
van Zutphen, LFM
van Lith, HA
机构：
[1] Univ Utrecht, Fac Vet Med, Dept Lab Anim Sci, Grad Sch Anim Hlth, NL-3508 TD Utrecht, Netherlands
[2] Univ Utrecht, Fac Vet Med, Dept Clin Sci Compan Anim, Grad Sch Anim Hlth, NL-3508 TD Utrecht, Netherlands
[3] Univ Utrecht, Fac Vet Med, Dept Equine Sci, Grad Sch Anim Hlth, NL-3508 TD Utrecht, Netherlands
[4] Univ Utrecht, Fac Vet Med, Dept Farm Anim Hlth, Grad Sch Anim Hlth, NL-3508 TD Utrecht, Netherlands
[5] Univ Utrecht, Fac Vet Med, Dept Nutr, Grad Sch Anim Hlth, NL-3508 TD Utrecht, Netherlands
来源：
EXPERIMENTAL BIOLOGY AND MEDICINE | 2002年 / 227卷 / 07期
关键词：
copper; inbred strain; liver; QTL; rat;
D O I：
10.1177/153537020222700718
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Significant differences in liver copper content have been observed between rat inbred strains. To define loci controlling this trait, the offspring (n = 190) from an (LEW/OlaHsd x BC/CpbU) F-2 intercross was genetically analyzed. From each F-2 animal, liver copper content was determined and genomic DNA was screened with polymorphic DNA markers. We found a major quantitative trait locus (QTL) for liver copper content in females on chromosome 2 and in males on chromosome 10. Both QTLs accounted for approximately 20% of the genetic variance. In addition, suggestive linkage for liver copper content was found on rat chromosomes 1, 8, 10, 12, 14, and 19. The regions on these chromosomes contain genes that are responsible for 9.0 - 15.5% of the genetic variance of liver copper content.
引用
收藏
页码：529 / 534
页数：6
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