Synthesis of novel anticancer iridoid derivatives and their cell cycle arrest and caspase dependent apoptosis

被引：14

作者：

Pandeti, Sukanya ^{[1
]}

Sharma, Komal ^{[2
]}

Bathula, Surendar Reddy ^{[2
]}

Tadigoppula, Narender ^{[1
]}

机构：

[1] CSIR, Cent Drug Res Inst, Med & Proc Chem Div, Lucknow 226001, Uttar Pradesh, India

[2] CSIR, Cent Drug Res Inst, Div Pharmaceut, Lucknow 226001, Uttar Pradesh, India

来源：

PHYTOMEDICINE | 2014年 / 21卷 / 03期

关键词：

7-O-trans-cinnamoyl 6 beta-hydroxyloganin derivatives; Arbortristoside-A; Anticancer agents; Apoptosis; Nyctanthes arbortristis; AGENTS;

D O I：

10.1016/j.phymed.2013.08.023

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Nyctanthes arbortristis Linn (Oleaceae) is widely distributed in sub-Himalayan regions and southwards to Godavari, India commonly known as Harsingar and Night Jasmine. In continuation of our drug discovery programme on Indian medicinal plants, we isolated arbortristoside-A (1) and 7-O-trans-cinnamoyl 6 beta-hydroxyloganin (2) from the seeds of N. Arbortristis, which exhibited moderate in vitro anticancer activity. Chemical transformation of 2 led to significant improvement in the activity in derivative 8 and 15 against HepG2 (human hepatocellular carcinoma), MCF-7 (breast adenocarcinoma) cell lines. The compounds 8 and 15 were also capable of cell cycle arrest and caspase dependent apoptosis in HepG2 cell lines. These iridoid derivatives hold promise for developing safer alternatives to the marketed drugs. (C) 2013 Elsevier GmbH. All rights reserved.

引用

页码：333 / 339

页数：7

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