Selective and independent activation of four motor fascicles using a four contact nerve-cuff electrode

被引:71
作者
Tarler, MD [1 ]
Mortimer, JT
机构
[1] Cleveland Med Devices, Cleveland, OH 44103 USA
[2] Case Western Reserve Univ, Dept Biomed Engn, Appl Neural Control Lab, Cleveland, OH 44106 USA
关键词
electrical stimulation; nerve cuff; neural prosthesis; selective activation;
D O I
10.1109/TNSRE.2004.828415
中图分类号
R318 [生物医学工程];
学科分类号
0831 ;
摘要
Any one of the four motor nerves in the cat sciatic nerve,could be activated selectively and independently, from threshold to saturation, using a self-sizing spiral cuff electrode containing four radially placed monopolar contacts. These studies were carried out in nine adult cats with acute implants. Of the 36 possible fascicles, 23 fascicles could be activated selectively with current stimuli applied to a single contact and ten of the remaining fascicles could be activated selectively with current stimuli applied to two contacts, ''field steering." In three experiments, time constraints precluded attempting selective activation through "field steering" techniques. In eight of the ten cases where "field steering" was used, a positive and a negative current source (anodic steering) were required to achieve the desired fascicle and in the remaining two cases, two negative current sources (cathodic steering) were required. The relative distance from the electrode contacts to each fascicle was well correlated to the order in which each fascicle was activated. In seven experiments, carried out in two animals, selective activation was verified by collision block techniques. The results of these experiments support the hypothesis that selective and independent activation of any of four motor fascicles in the cat sciatic nerve is possible using a four contact self-sizing spiral cuff electrode. Furthermore, in a more general case, these results support the concept of a "tunable" electrode that is capable of "steering" the excitation from an undesirable location to a preferred location.
引用
收藏
页码:251 / 257
页数:7
相关论文
共 21 条
[1]  
ATZBERGER DG, 1998, TISSE RESPONSE IMPLA
[2]   Transverse tripolar stimulation of peripheral nerve: a modelling study of spatial selectivity [J].
Deurloo, KEI ;
Holsheimer, J ;
Boom, HBK .
MEDICAL & BIOLOGICAL ENGINEERING & COMPUTING, 1998, 36 (01) :66-74
[3]   Position-selective activation of peripheral nerve fibers with a cuff electrode [J].
Goodall, EV ;
deBreij, JF ;
Holsheimer, J .
IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING, 1996, 43 (08) :851-856
[4]   Quantification of recruitment properties of multiple contact cuff electrodes [J].
Grill Jr., W.M. ;
Mortimer, J.T. .
IEEE Transactions on Rehabilitation Engineering, 1996, 4 (02) :49-62
[5]   The effect of stimulus pulse duration on selectivity of neural stimulation [J].
Grill, WM ;
Mortimer, JT .
IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING, 1996, 43 (02) :161-166
[6]   Non-invasive measurement of the input-output properties of peripheral nerve stimulating electrodes [J].
Grill, WM ;
Mortimer, JT .
JOURNAL OF NEUROSCIENCE METHODS, 1996, 65 (01) :43-50
[7]  
GRILL WM, 1991, P ANN INT C IEEE ENG, V13, P904
[8]   An implanted upper-extremity neuroprosthesis - Follow-up of five patients [J].
Kilgore, KL ;
Peckham, PH ;
Keith, MW ;
Thrope, GB ;
Wuolle, KS ;
Bryden, AM ;
Hart, RL .
JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME, 1997, 79A (04) :533-541
[9]   CAT HINDLIMB MUSCLES EXERT SUBSTANTIAL TORQUES OUTSIDE THE SAGITTAL PLANE [J].
LAWRENCE, JH ;
NICHOLS, TR ;
ENGLISH, AW .
JOURNAL OF NEUROPHYSIOLOGY, 1993, 69 (01) :282-285
[10]   SELECTIVE ACTIVATION OF MUSCLES USING PERIPHERAL-NERVE ELECTRODES [J].
MCNEAL, DR ;
BOWMAN, BR .
MEDICAL & BIOLOGICAL ENGINEERING & COMPUTING, 1985, 23 (03) :249-253