A new three-way variant t(15;22;17)(q22;q11.2;q21) in acute promyelocytic leukemia

被引：4
作者：
Kato, Takayasu [1 ]
Hangaishi, Akira [1 ]
Ichikawa, Motoshi [1 ]
Motokura, Toru [1 ]
Takahashi, Tsuyoshi [1 ]
Kurokawa, Mineo [1 ]
机构：
[1] Univ Tokyo, Grad Sch Med, Dept Hematol & Oncol, Bunkyo Ku, Tokyo 1138655, Japan
来源：
INTERNATIONAL JOURNAL OF HEMATOLOGY | 2009年 / 89卷 / 02期
关键词：
Three-way translocation; APL; PML-RARA; IN-SITU HYBRIDIZATION; COMPLEX TRANSLOCATION; MOLECULAR ANALYSIS; ALPHA GENE; RAR-ALPHA; CHROMOSOME-17; PML/RARA; T(15/17); PATIENT; CONFIRMATION;
D O I：
10.1007/s12185-008-0253-6
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Acute promyelocytic leukemia (APL) is characterized by the t(15;17)(q22;q21), which results in the fusion of the promyelocytic leukemia (PML) gene at 15q22 with the retinoic acid alpha-receptor (RARA) at 17q21. We report the case of a 44-year-old man with APL carrying a new complex variant translocation (15;22;17). Karyotypic analysis with G-banding of bone marrow cells revealed t(15;22;17) (q22;q11.2;q21). Fluorescence in situ hybridization with a PML/RARA dual-color DNA probe showed the fusion signals. RT-PCR analysis showed long-form PML/RARA fusion transcripts. A complete remission was attained with a course of conventional chemotherapy with all-trans retinoic acid (ATRA). This is the first report of a new three-way translocation of 22q11 involvement with APL.
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收藏
页码：204 / 208
页数：5
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