共 103 条
Silicon Quantum Dots for Biological Applications
被引:156
作者:
Chinnathambi, Shanmugavel
[1
]
Chen, Song
[2
,3
]
Ganesan, Singaravelu
[1
]
Hanagata, Nobutaka
[4
,5
]
机构:
[1] Anna Univ, Dept Med Phys, Madras 600025, Tamil Nadu, India
[2] Natl Inst Mat Sci, Tsukuba, Ibaraki 3050047, Japan
[3] Natl Inst Mat Sci, Biomat Unit, Tsukuba, Ibaraki 3050047, Japan
[4] Natl Inst Mat Sci, Nanotechnol Innovat Stn, Tsukuba, Ibaraki 3050047, Japan
[5] Hokkaido Univ, Grad Sch Life Sci, Kita Ku, Sapporo, Hokkaido 0600812, Japan
基金:
日本学术振兴会;
关键词:
bioimaging;
drug delivery;
quantum dots;
silicon;
HIGHLY-LUMINESCENT;
PLASMA SYNTHESIS;
DEPENDENT PHOTOLUMINESCENCE;
SURFACE FUNCTIONALIZATION;
NANOPARTICLES SYNTHESIS;
LIVE CELLS;
IN-VITRO;
NANOCRYSTALS;
SI;
FLUORESCENT;
D O I:
10.1002/adhm.201300157
中图分类号:
R318 [生物医学工程];
学科分类号:
0831 ;
摘要:
Semiconductor nanoparticles (or quantum dots, QDs) exhibit unique optical and electronic properties such as size-controlled fluorescence, high quantum yields, and stability against photobleaching. These properties allow QDs to be used as optical labels for multiplexed imaging and in drug delivery detection systems. Luminescent silicon QDs and surface-modified silicon QDs have also been developed as potential minimally toxic fluorescent probes for bioapplications. Silicon, a well-known power electronic semiconductor material, is considered an extremely biocompatible material, in particular with respect to blood. This review article summarizes existing knowledge related to and recent research progress made in the methods for synthesizing silicon QDs, as well as their optical properties and surface-modification processes. In addition, drug delivery systems and in vitro and in vivo imaging applications that use silicon QDs are also discussed.
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页码:10 / 29
页数:20
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