Silicon Quantum Dots for Biological Applications

被引:156
作者
Chinnathambi, Shanmugavel [1 ]
Chen, Song [2 ,3 ]
Ganesan, Singaravelu [1 ]
Hanagata, Nobutaka [4 ,5 ]
机构
[1] Anna Univ, Dept Med Phys, Madras 600025, Tamil Nadu, India
[2] Natl Inst Mat Sci, Tsukuba, Ibaraki 3050047, Japan
[3] Natl Inst Mat Sci, Biomat Unit, Tsukuba, Ibaraki 3050047, Japan
[4] Natl Inst Mat Sci, Nanotechnol Innovat Stn, Tsukuba, Ibaraki 3050047, Japan
[5] Hokkaido Univ, Grad Sch Life Sci, Kita Ku, Sapporo, Hokkaido 0600812, Japan
基金
日本学术振兴会;
关键词
bioimaging; drug delivery; quantum dots; silicon; HIGHLY-LUMINESCENT; PLASMA SYNTHESIS; DEPENDENT PHOTOLUMINESCENCE; SURFACE FUNCTIONALIZATION; NANOPARTICLES SYNTHESIS; LIVE CELLS; IN-VITRO; NANOCRYSTALS; SI; FLUORESCENT;
D O I
10.1002/adhm.201300157
中图分类号
R318 [生物医学工程];
学科分类号
0831 ;
摘要
Semiconductor nanoparticles (or quantum dots, QDs) exhibit unique optical and electronic properties such as size-controlled fluorescence, high quantum yields, and stability against photobleaching. These properties allow QDs to be used as optical labels for multiplexed imaging and in drug delivery detection systems. Luminescent silicon QDs and surface-modified silicon QDs have also been developed as potential minimally toxic fluorescent probes for bioapplications. Silicon, a well-known power electronic semiconductor material, is considered an extremely biocompatible material, in particular with respect to blood. This review article summarizes existing knowledge related to and recent research progress made in the methods for synthesizing silicon QDs, as well as their optical properties and surface-modification processes. In addition, drug delivery systems and in vitro and in vivo imaging applications that use silicon QDs are also discussed.
引用
收藏
页码:10 / 29
页数:20
相关论文
共 103 条
[1]   Highly Luminescent and Nontoxic Amine-Capped Nanoparticles from Porous Silicon: Synthesis and Their Use in Biomedical Imaging [J].
Ahire, Jayshree H. ;
Wang, Qi ;
Coxon, Paul R. ;
Malhotra, Girish ;
Brydson, Rik ;
Chen, Rongjun ;
Chao, Yimin .
ACS APPLIED MATERIALS & INTERFACES, 2012, 4 (06) :3285-3292
[2]   In vitro immunogenicity of silicon-based micro- and nanostructured surfaces [J].
Ainslie, Kristy M. ;
Tao, Sarah L. ;
Popat, Ketul C. ;
Desai, Tejal A. .
ACS NANO, 2008, 2 (05) :1076-1084
[3]   Quantum dots as cellular probes [J].
Alivisatos, AP ;
Gu, WW ;
Larabell, C .
ANNUAL REVIEW OF BIOMEDICAL ENGINEERING, 2005, 7 :55-76
[4]   Semiconductor clusters, nanocrystals, and quantum dots [J].
Alivisatos, AP .
SCIENCE, 1996, 271 (5251) :933-937
[5]   Routes to Achieving High Quantum Yield Luminescence from Gas-Phase-Produced Silicon Nanocrystals [J].
Anthony, Rebecca J. ;
Rowe, David J. ;
Stein, Matthias ;
Yang, Jihua ;
Kortshagen, Uwe .
ADVANCED FUNCTIONAL MATERIALS, 2011, 21 (21) :4042-4046
[6]   Quantum dots as photosensitizers? [J].
Bakalova, R ;
Ohba, H ;
Zhelev, Z ;
Ishikawa, M ;
Baba, Y .
NATURE BIOTECHNOLOGY, 2004, 22 (11) :1360-1361
[7]   Room temperature solution synthesis of alkyl-capped tetrahedral shaped silicon nanocrystals [J].
Baldwin, RK ;
Pettigrew, KA ;
Garno, JC ;
Power, PP ;
Liu, GY ;
Kauzlarich, SM .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2002, 124 (07) :1150-1151
[8]   Observation of a magic discrete family of ultrabright Si nanoparticles [J].
Belomoin, G ;
Therrien, J ;
Smith, A ;
Rao, S ;
Twesten, R ;
Chaieb, S ;
Nayfeh, MH ;
Wagner, L ;
Mitas, L .
APPLIED PHYSICS LETTERS, 2002, 80 (05) :841-843
[9]   A low-temperature solution phase route for the synthesis of silicon nanoclusters [J].
Bley, RA ;
Kauzlarich, SM .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1996, 118 (49) :12461-12462
[10]   ELECTRONIC SPECTROSCOPY AND PHOTOPHYSICS OF SI NANOCRYSTALS - RELATIONSHIP TO BULK C-SI AND POROUS SI [J].
BRUS, LE ;
SZAJOWSKI, PF ;
WILSON, WL ;
HARRIS, TD ;
SCHUPPLER, S ;
CITRIN, PH .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1995, 117 (10) :2915-2922