Microbiome;
Diet;
Metagenomics;
Dog microbiome;
Human microbiome;
Mouse microbiome;
Pig microbiome;
LOW-CARBOHYDRATE;
HIGH-PROTEIN;
WEIGHT-LOSS;
OBESITY;
ABUNDANCE;
CATALOG;
MODEL;
D O I:
10.1186/s40168-018-0450-3
中图分类号:
Q93 [微生物学];
学科分类号:
071005 ;
100705 ;
摘要:
Background: Gut microbes influence their hosts in many ways, in particular by modulating the impact of diet. These effects have been studied most extensively in humans and mice. In this work, we used whole genome metagenomics to investigate the relationship between the gut metagenomes of dogs, humans, mice, and pigs. Results: We present a dog gut microbiome gene catalog containing 1,247,405 genes (based on 129 metagenomes and a total of 1.9 terabasepairs of sequencing data). Based on this catalog and taxonomic abundance profiling, we show that the dog microbiome is closer to the human microbiome than the microbiome of either pigs or mice. To investigate this similarity in terms of response to dietary changes, we report on a randomized intervention with two diets (high-protein/low-carbohydrate vs. lower protein/higher carbohydrate). We show that diet has a large and reproducible effect on the dog microbiome, independent of breed or sex. Moreover, the responses were in agreement with those observed in previous human studies. Conclusions: We conclude that findings in dogs may be predictive of human microbiome results. In particular, a novel finding is that overweight or obese dogs experience larger compositional shifts than lean dogs in response to a high-protein diet.
机构:
Tel Aviv Univ, Sackler Fac Exact Sci, Dept Stat & Operat Res, IL-69978 Tel Aviv, IsraelTel Aviv Univ, Sackler Fac Exact Sci, Dept Stat & Operat Res, IL-69978 Tel Aviv, Israel
Benjamini, Yoav
;
Krieger, Abba M.
论文数: 0引用数: 0
h-index: 0
机构:Tel Aviv Univ, Sackler Fac Exact Sci, Dept Stat & Operat Res, IL-69978 Tel Aviv, Israel
Krieger, Abba M.
;
Yekutieli, Daniel
论文数: 0引用数: 0
h-index: 0
机构:Tel Aviv Univ, Sackler Fac Exact Sci, Dept Stat & Operat Res, IL-69978 Tel Aviv, Israel
机构:
Harvard Univ, FAS Ctr Syst Biol, Cambridge, MA 02138 USA
Harvard Univ, Soc Fellows, Cambridge, MA 02138 USAHarvard Univ, FAS Ctr Syst Biol, Cambridge, MA 02138 USA
David, Lawrence A.
;
Maurice, Corinne F.
论文数: 0引用数: 0
h-index: 0
机构:
Harvard Univ, FAS Ctr Syst Biol, Cambridge, MA 02138 USAHarvard Univ, FAS Ctr Syst Biol, Cambridge, MA 02138 USA
Maurice, Corinne F.
;
Carmody, Rachel N.
论文数: 0引用数: 0
h-index: 0
机构:
Harvard Univ, FAS Ctr Syst Biol, Cambridge, MA 02138 USAHarvard Univ, FAS Ctr Syst Biol, Cambridge, MA 02138 USA
Carmody, Rachel N.
;
Gootenberg, David B.
论文数: 0引用数: 0
h-index: 0
机构:
Harvard Univ, FAS Ctr Syst Biol, Cambridge, MA 02138 USAHarvard Univ, FAS Ctr Syst Biol, Cambridge, MA 02138 USA
Gootenberg, David B.
;
Button, Julie E.
论文数: 0引用数: 0
h-index: 0
机构:
Harvard Univ, FAS Ctr Syst Biol, Cambridge, MA 02138 USAHarvard Univ, FAS Ctr Syst Biol, Cambridge, MA 02138 USA
Button, Julie E.
;
Wolfe, Benjamin E.
论文数: 0引用数: 0
h-index: 0
机构:
Harvard Univ, FAS Ctr Syst Biol, Cambridge, MA 02138 USAHarvard Univ, FAS Ctr Syst Biol, Cambridge, MA 02138 USA
Wolfe, Benjamin E.
;
Ling, Alisha V.
论文数: 0引用数: 0
h-index: 0
机构:
Harvard Univ, Sch Med, Childrens Hosp Boston, Div Endocrinol, Boston, MA 02115 USAHarvard Univ, FAS Ctr Syst Biol, Cambridge, MA 02138 USA
Ling, Alisha V.
;
Devlin, A. Sloan
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif San Francisco, Dept Bioengn & Therapeut Sci, San Francisco, CA 94158 USA
Univ Calif San Francisco, Calif Inst Quantitat Biosci, San Francisco, CA 94158 USAHarvard Univ, FAS Ctr Syst Biol, Cambridge, MA 02138 USA
Devlin, A. Sloan
;
Varma, Yug
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif San Francisco, Dept Bioengn & Therapeut Sci, San Francisco, CA 94158 USA
Univ Calif San Francisco, Calif Inst Quantitat Biosci, San Francisco, CA 94158 USAHarvard Univ, FAS Ctr Syst Biol, Cambridge, MA 02138 USA
Varma, Yug
;
Fischbach, Michael A.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif San Francisco, Dept Bioengn & Therapeut Sci, San Francisco, CA 94158 USA
Univ Calif San Francisco, Calif Inst Quantitat Biosci, San Francisco, CA 94158 USAHarvard Univ, FAS Ctr Syst Biol, Cambridge, MA 02138 USA
Fischbach, Michael A.
;
Biddinger, Sudha B.
论文数: 0引用数: 0
h-index: 0
机构:
Harvard Univ, Sch Med, Childrens Hosp Boston, Div Endocrinol, Boston, MA 02115 USAHarvard Univ, FAS Ctr Syst Biol, Cambridge, MA 02138 USA
Biddinger, Sudha B.
;
Dutton, Rachel J.
论文数: 0引用数: 0
h-index: 0
机构:
Harvard Univ, FAS Ctr Syst Biol, Cambridge, MA 02138 USAHarvard Univ, FAS Ctr Syst Biol, Cambridge, MA 02138 USA
Dutton, Rachel J.
;
Turnbaugh, Peter J.
论文数: 0引用数: 0
h-index: 0
机构:
Harvard Univ, FAS Ctr Syst Biol, Cambridge, MA 02138 USAHarvard Univ, FAS Ctr Syst Biol, Cambridge, MA 02138 USA
机构:
WALTHAM Ctr Pet Nutr, Melton Mowbray, Leics, EnglandWALTHAM Ctr Pet Nutr, Melton Mowbray, Leics, England
Deusch, Oliver
;
O'Flynn, Ciaran
论文数: 0引用数: 0
h-index: 0
机构:
WALTHAM Ctr Pet Nutr, Melton Mowbray, Leics, EnglandWALTHAM Ctr Pet Nutr, Melton Mowbray, Leics, England
O'Flynn, Ciaran
;
Colyer, Alison
论文数: 0引用数: 0
h-index: 0
机构:
WALTHAM Ctr Pet Nutr, Melton Mowbray, Leics, EnglandWALTHAM Ctr Pet Nutr, Melton Mowbray, Leics, England
Colyer, Alison
;
Morris, Penelope
论文数: 0引用数: 0
h-index: 0
机构:
WALTHAM Ctr Pet Nutr, Melton Mowbray, Leics, EnglandWALTHAM Ctr Pet Nutr, Melton Mowbray, Leics, England
Morris, Penelope
;
Allaway, David
论文数: 0引用数: 0
h-index: 0
机构:
WALTHAM Ctr Pet Nutr, Melton Mowbray, Leics, EnglandWALTHAM Ctr Pet Nutr, Melton Mowbray, Leics, England
Allaway, David
;
Jones, Paul G.
论文数: 0引用数: 0
h-index: 0
机构:
WALTHAM Ctr Pet Nutr, Melton Mowbray, Leics, EnglandWALTHAM Ctr Pet Nutr, Melton Mowbray, Leics, England
Jones, Paul G.
;
Swanson, Kelly S.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Illinois, Dept Anim Sci, Urbana, IL 61801 USA
Univ Illinois, Div Nutr Sci, Urbana, IL 61801 USA
Univ Illinois, Dept Vet Clin Med, Urbana, IL 61801 USAWALTHAM Ctr Pet Nutr, Melton Mowbray, Leics, England
机构:
Tel Aviv Univ, Sackler Fac Exact Sci, Dept Stat & Operat Res, IL-69978 Tel Aviv, IsraelTel Aviv Univ, Sackler Fac Exact Sci, Dept Stat & Operat Res, IL-69978 Tel Aviv, Israel
Benjamini, Yoav
;
Krieger, Abba M.
论文数: 0引用数: 0
h-index: 0
机构:Tel Aviv Univ, Sackler Fac Exact Sci, Dept Stat & Operat Res, IL-69978 Tel Aviv, Israel
Krieger, Abba M.
;
Yekutieli, Daniel
论文数: 0引用数: 0
h-index: 0
机构:Tel Aviv Univ, Sackler Fac Exact Sci, Dept Stat & Operat Res, IL-69978 Tel Aviv, Israel
机构:
Harvard Univ, FAS Ctr Syst Biol, Cambridge, MA 02138 USA
Harvard Univ, Soc Fellows, Cambridge, MA 02138 USAHarvard Univ, FAS Ctr Syst Biol, Cambridge, MA 02138 USA
David, Lawrence A.
;
Maurice, Corinne F.
论文数: 0引用数: 0
h-index: 0
机构:
Harvard Univ, FAS Ctr Syst Biol, Cambridge, MA 02138 USAHarvard Univ, FAS Ctr Syst Biol, Cambridge, MA 02138 USA
Maurice, Corinne F.
;
Carmody, Rachel N.
论文数: 0引用数: 0
h-index: 0
机构:
Harvard Univ, FAS Ctr Syst Biol, Cambridge, MA 02138 USAHarvard Univ, FAS Ctr Syst Biol, Cambridge, MA 02138 USA
Carmody, Rachel N.
;
Gootenberg, David B.
论文数: 0引用数: 0
h-index: 0
机构:
Harvard Univ, FAS Ctr Syst Biol, Cambridge, MA 02138 USAHarvard Univ, FAS Ctr Syst Biol, Cambridge, MA 02138 USA
Gootenberg, David B.
;
Button, Julie E.
论文数: 0引用数: 0
h-index: 0
机构:
Harvard Univ, FAS Ctr Syst Biol, Cambridge, MA 02138 USAHarvard Univ, FAS Ctr Syst Biol, Cambridge, MA 02138 USA
Button, Julie E.
;
Wolfe, Benjamin E.
论文数: 0引用数: 0
h-index: 0
机构:
Harvard Univ, FAS Ctr Syst Biol, Cambridge, MA 02138 USAHarvard Univ, FAS Ctr Syst Biol, Cambridge, MA 02138 USA
Wolfe, Benjamin E.
;
Ling, Alisha V.
论文数: 0引用数: 0
h-index: 0
机构:
Harvard Univ, Sch Med, Childrens Hosp Boston, Div Endocrinol, Boston, MA 02115 USAHarvard Univ, FAS Ctr Syst Biol, Cambridge, MA 02138 USA
Ling, Alisha V.
;
Devlin, A. Sloan
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif San Francisco, Dept Bioengn & Therapeut Sci, San Francisco, CA 94158 USA
Univ Calif San Francisco, Calif Inst Quantitat Biosci, San Francisco, CA 94158 USAHarvard Univ, FAS Ctr Syst Biol, Cambridge, MA 02138 USA
Devlin, A. Sloan
;
Varma, Yug
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif San Francisco, Dept Bioengn & Therapeut Sci, San Francisco, CA 94158 USA
Univ Calif San Francisco, Calif Inst Quantitat Biosci, San Francisco, CA 94158 USAHarvard Univ, FAS Ctr Syst Biol, Cambridge, MA 02138 USA
Varma, Yug
;
Fischbach, Michael A.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif San Francisco, Dept Bioengn & Therapeut Sci, San Francisco, CA 94158 USA
Univ Calif San Francisco, Calif Inst Quantitat Biosci, San Francisco, CA 94158 USAHarvard Univ, FAS Ctr Syst Biol, Cambridge, MA 02138 USA
Fischbach, Michael A.
;
Biddinger, Sudha B.
论文数: 0引用数: 0
h-index: 0
机构:
Harvard Univ, Sch Med, Childrens Hosp Boston, Div Endocrinol, Boston, MA 02115 USAHarvard Univ, FAS Ctr Syst Biol, Cambridge, MA 02138 USA
Biddinger, Sudha B.
;
Dutton, Rachel J.
论文数: 0引用数: 0
h-index: 0
机构:
Harvard Univ, FAS Ctr Syst Biol, Cambridge, MA 02138 USAHarvard Univ, FAS Ctr Syst Biol, Cambridge, MA 02138 USA
Dutton, Rachel J.
;
Turnbaugh, Peter J.
论文数: 0引用数: 0
h-index: 0
机构:
Harvard Univ, FAS Ctr Syst Biol, Cambridge, MA 02138 USAHarvard Univ, FAS Ctr Syst Biol, Cambridge, MA 02138 USA
机构:
WALTHAM Ctr Pet Nutr, Melton Mowbray, Leics, EnglandWALTHAM Ctr Pet Nutr, Melton Mowbray, Leics, England
Deusch, Oliver
;
O'Flynn, Ciaran
论文数: 0引用数: 0
h-index: 0
机构:
WALTHAM Ctr Pet Nutr, Melton Mowbray, Leics, EnglandWALTHAM Ctr Pet Nutr, Melton Mowbray, Leics, England
O'Flynn, Ciaran
;
Colyer, Alison
论文数: 0引用数: 0
h-index: 0
机构:
WALTHAM Ctr Pet Nutr, Melton Mowbray, Leics, EnglandWALTHAM Ctr Pet Nutr, Melton Mowbray, Leics, England
Colyer, Alison
;
Morris, Penelope
论文数: 0引用数: 0
h-index: 0
机构:
WALTHAM Ctr Pet Nutr, Melton Mowbray, Leics, EnglandWALTHAM Ctr Pet Nutr, Melton Mowbray, Leics, England
Morris, Penelope
;
Allaway, David
论文数: 0引用数: 0
h-index: 0
机构:
WALTHAM Ctr Pet Nutr, Melton Mowbray, Leics, EnglandWALTHAM Ctr Pet Nutr, Melton Mowbray, Leics, England
Allaway, David
;
Jones, Paul G.
论文数: 0引用数: 0
h-index: 0
机构:
WALTHAM Ctr Pet Nutr, Melton Mowbray, Leics, EnglandWALTHAM Ctr Pet Nutr, Melton Mowbray, Leics, England
Jones, Paul G.
;
Swanson, Kelly S.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Illinois, Dept Anim Sci, Urbana, IL 61801 USA
Univ Illinois, Div Nutr Sci, Urbana, IL 61801 USA
Univ Illinois, Dept Vet Clin Med, Urbana, IL 61801 USAWALTHAM Ctr Pet Nutr, Melton Mowbray, Leics, England