Omadacycline: A Newly Approved Antibacterial from the Class of Tetracyclines

被引：33

作者：

Duraes, Fernando ^{[1
,2
]}

Sousa, Emilia ^{[1
,2
]}

机构：

[1] Univ Porto, Lab Organ & Pharmaceut Chem, Dept Chem Sci, Fac Pharm, Rua Jorge Viterbo Ferreira 228, P-4050313 Porto, Portugal

[2] Univ Porto, CIIMAR, Interdisciplinary Ctr Marine & Environm Res, Ave Gen Norton Matos P2, P-4450208 Matosinhos, Portugal

来源：

PHARMACEUTICALS | 2019年 / 12卷 / 02期

关键词：

Omadacycline; aminomethylcycline; tetracycline; antibacterial; protein synthesis inhibitor; FDA approved; IN-VITRO; AMINOMETHYLCYCLINE; MYCOPLASMAS; DISCOVERY; SKIN;

D O I：

10.3390/ph12020063

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Omadacycline (Nuzyra (R)) is a new aminomethylcycline, approved by the U. S. Food and Drug Administration in 2018, as a tetracycline antibacterial. It can be used in community-acquired pneumonia and in acute bacterial skin and skin-structure infections. It was developed and is commercialized by Paratek Pharmaceuticals. It is a semisynthetic compound, derived from minocycline, capable of evading widely distributed efflux and target protection antibacterial resistance mechanisms and has demonstrated activity in a broad spectrum of bacteria.

引用

页数：9

共 35 条

[1]

Abrahamian FM, 2018, OPEN FORUM INFECT DI, V5, pS412, DOI DOI 10.1093/ofid/ofy210.1178

[2] A brief history of the antibiotic era: lessons learned and challenges for the future [J].

Aminov, Rustam I. .

FRONTIERS IN MICROBIOLOGY, 2010, 1

[3] Omadacycline Enters the Ring: A New Antimicrobial Contender [J].

Barber, Katie E. ;

Bell, Alison M. ;

Wingler, Mary Joyce B. ;

Wagner, Jamie L. ;

Stover, Kayla R. .

PHARMACOTHERAPY, 2018, 38 (12) :1194-1204

[4] Omadacycline - The Newest Tetracycline [J].

Chambers, Henry F. .

NEW ENGLAND JOURNAL OF MEDICINE, 2019, 380 (06) :588-589

[5] Mycoplasmas and Their Antibiotic Resistance: The Problems and Prospects in Controlling Infections [J].

Chernova, O. A. ;

Medvedeva, E. S. ;

Mouzykantov', A. A. ;

Baranova, N. B. ;

Chernov, V. M. .

ACTA NATURAE, 2016, 8 (02) :24-34

[6] Return of the tetracyclines: omadacycline, a novel aminomethylcycline antimicrobial [J].

Cho, J. C. ;

Childs-Kean, L. M. ;

Zmarlicka, M. T. ;

Crotty, M. P. .

DRUGS OF TODAY, 2018, 54 (03) :209-217

[7] Omadacycline: A New Tetracycline Antibiotic [J].

Dougherty, John A. ;

Sucher, Allana J. ;

Chahine, Elias B. ;

Shihadeh, Katherine C. .

ANNALS OF PHARMACOTHERAPY, 2019, 53 (05) :486-500

[8] Mechanism of Action of the Novel Aminomethylcycline Antibiotic Omadacycline [J].

Draper, Michael P. ;

Weir, S. ;

Macone, A. ;

Donatelli, J. ;

Trieber, C. A. ;

Tanaka, S. K. ;

Levy, Stuart B. .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2014, 58 (03) :1279-1283

[9] Medicinal Chemistry Updates on Bacterial Efflux Pump Modulators [J].

Duraes, Fernando ;

Pinto, Madalena ;

Sousa, Emilia .

CURRENT MEDICINAL CHEMISTRY, 2018, 25 (42) :6030-6069

[10] Minimal inhibitory concentration of omadacycline and doxycycline against bacterial isolates with known tetracycline resistance determinants [J].

Fluit, Ad C. ;

van Gorkum, Sjoukje ;

Vlooswijk, Judith .

DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE, 2019, 94 (01) :78-80

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