Synthesis and anti-tumor activities of some new pyridines and pyrazolo [1,5-a]pyrimidines

被引：126

作者：

Ahmed, Osama M. ^{[1
]}

Mohamed, Mahmoud A. ^{[3
]}

Ahmed, Rasha R. ^{[2
]}

Ahmed, Sayed A. ^{[4
]}

机构：

[1] Beni Suef Univ, Fac Sci, Div Physiol, Dept Zool, Bani Suwayf 62514, Egypt

[2] Beni Suef Univ, Fac Sci, Cytol & Histol Div, Dept Zool, Bani Suwayf 62514, Egypt

[3] Beni Suef Univ, Fac Ind Educ, Dept Text, Bani Suwayf 62514, Egypt

[4] Beni Suef Univ, Fac Sci, Div Organ Chem, Dept Chem, Bani Suwayf 62514, Egypt

来源：

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 2009年 / 44卷 / 09期

关键词：

2-Acetylnaphthalene; Cyanoacetamide; Cyanothioacetamide; 3-Aminopyrazols; Anti-tumor cytotoxicity; BIOLOGICAL-ACTIVITY; CYTOTOXICITY; INHIBITORS; ANALOGS; METHOTREXATE; CELLS; ACID;

D O I：

10.1016/j.ejmech.2009.03.042

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Cyclocondensation of cyanoacetamide, cyanothioacetamide and 3-aminopyrazols with sodium salt of 3-hydroxy-1-(2-naphthyl)prop-2-en-1-one gives pyridin-2-one, pyridin-2(1H)-thione, and pyrazolo[1,5-a]pyrimidine derivatives. These derivatives showed potent anti-tumor cytotoxic activity in vitro using different human cancer cell lines. (C) 2009 Elsevier Masson SAS. All rights reserved.

引用

页码：3519 / 3523

页数：5

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