Combined photothermal-photodynamic therapy by indocyanine green loaded polydopamine nanoparticles enhances anti-mammary gland tumor efficacy

被引：23

作者：

Liu, Xu ^{[1
]}

Xu, Na ^{[1
]}

Pu, Ximing ^{[1
]}

Wang, Juan ^{[1
]}

Liao, Xiaoming ^{[1
]}

Huang, Zhongbing ^{[1
]}

Yin, Guangfu ^{[1
]}

机构：

[1] Sichuan Univ, Coll Biomed Engn, 24 South 1st Sect,1st Ring Rd, Chengdu 610065, Peoples R China

来源：

JOURNAL OF MATERIALS CHEMISTRY B | 2022年 / 10卷 / 24期

基金：

国家重点研发计划;

关键词：

CANCER; COMBINATION; LIPOSOMES; AGENT;

D O I：

10.1039/d2tb00565d

中图分类号：

TB3 [工程材料学]; R318.08 [生物材料学];

学科分类号：

0805 ; 080501 ; 080502 ;

摘要：

Various nano-targeted drug delivery systems have been developed for combined photothermal-photodynamic (PTT-PDT) treatment of tumors due to better outcomes compared with monomodality therapy. Here, we constructed a facile two-step method without core templates to obtain indocyanine green (ICG) loaded-hyaluronic acid (HA) surface-coated polydopamine nanoparticles (IIPH). The prepared nanoparticles demonstrated an excellent photothermal conversion capacity and efficient singlet oxygen production. Both in vitro and in vivo studies proved that IIPH could significantly inhibit the growth of tumor by PTT-PDT combinational treatment. All the results indicated that IIPH NPs hold great potential to be utilized as a new photothermal-photodynamic composite for cancer treatment.

引用

页码：4605 / 4614

页数：10