Chronic predator scent stress alters serotonin and dopamine levels in the rat thalamus and hypothalamus, respectively

被引：12
作者：
Dremencov, Eliyahu [1 ,2 ,3 ]
Lapshin, Maxim [3 ]
Komelkova, Maria [3 ]
Alliluev, Anatoli [3 ]
Tseilikman, Olga [3 ]
Karpenko, Marina [4 ]
Pestereva, Nina [4 ]
Manukhina, Eugenia [5 ,6 ]
Downey, H. Fred [6 ]
Tseilikman, Vadim [3 ]
机构：
[1] Slovak Acad Sci, Ctr Biosci, Inst Mol Physiol & Genet, Bratislava, Slovakia
[2] Slovak Acad Sci, Biomed Res Ctr, Inst Expt Endocrinol, Bratislava, Slovakia
[3] South Ural State Univ, Sch Med Biol, 76 Lenin Ave, Chelyabinsk 454080, Russia
[4] Inst Expt Med, St Petersburg, Russia
[5] Inst Gen Pathol & Pathophysiol, Moscow, Russia
[6] Univ North Texas Hlth Sci Ctr, Ft Worth, TX USA
来源：
GENERAL PHYSIOLOGY AND BIOPHYSICS | 2019年 / 38卷 / 02期
基金：
俄罗斯科学基金会;
关键词：
Post-traumatic stress disorder; Predator scent stress; Serotonin; Norepinephrine; Dopamine; HPLC;
D O I：
10.4149/gpb_2019003
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The aim of this study was to investigate the effect of chronic predator scent stress (PSS) on monoamine levels in rat thalamus and hypothalamus. Rats were exposed to the PSS (sand containing cat urine) for ten minutes daily for ten days. Control animals were exposed to the sand containing clean water. Fifteen days later, rats' behavior and thalamic and hypothalamic levels of monoamines were analyzed. PSS rats had elevated anxiety, increased thalamic serotonin and decreased hypothalamic dopamine concentrations. This decrease in hypothalamic dopamine may explain, at least in part, lowered corticosterone levels observed in PSS animals in our previous studies.
引用
收藏
页码：187 / 190
页数：4
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