Anti-genotoxic hydrazide from Crinum defixum

被引：14
作者：
Bordoloi, Manobjyoti [1 ]
Kotoky, Rumi [2 ]
Mahanta, Jiban J. [2 ]
Sarma, Tarun C. [2 ]
Kanjilal, Purnendu B. [2 ]
机构：
[1] CSIR, NE Inst Sci & Technol, Nat Prod Chem Div, Jorhat 785006, Assam, India
[2] CSIR, NE Inst Sci & Technol, Med Aromat & Econ Plants Div, Jorhat 785006, Assam, India
来源：
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 2009年 / 44卷 / 06期
关键词：
Crinum defixum Ker-Gawl; Amaryllidaceae; Bon-naharu; Anti-genotoxicity; Onion root tip assay; (E)-N '-[(E)-2-Butenoyl]-2-butenoylhydrazide; AQUEOUS EXTRACT; AMARYLLIDACEAE; L;
D O I：
10.1016/j.ejmech.2008.09.041
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Crinum defixum Ker-Gawl popularly known as Bon-naharu (meaning wild garlic) in Assam. It is found abundantly growing wild on riverbanks of Dhansiri River in Golaghat District of Assam. It is used as ethnomedicine in this part of India for a number of ailments. Bioassay guided chemical investigation of the bulbs of Crinum defixum Ker-Gawl afforded to isolate a new hydrazide derivative and its structure was determined as (E)-N'-[(E)-2-butenoyl]-2-butenoylhydrazide by spectroscopic methods. The compound was assayed for anti-genotoxic activity by onion root tip assay (by observing different types of chromosomal aberrations such as chromosomal bridges, stickiness, delayed anaphase, polyploidy and vagrant chromosome). The phyto-compound was found to have anti-genotoxic activity and imparted a clear dose dependent protective effect against the genotoxic effect of H2O2. Further, the compound seems to be more effective against clastogenic aberrations than physiological aberration at the highest concentration used (250 ppm). (C) 2008 Elsevier Masson SAS. All rights reserved.
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收藏
页码：2754 / 2757
页数：4
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