Role of isocitrate dehydrogenase 1/2 (IDH 1/2) gene mutations in human tumors

被引：1

作者：

Liu, Xiang ^{[1
]}

Ling, Zhi-Qiang ^{[1
]}

机构：

[1] Zhejiang Prov Canc Hosp, Zhejiang Canc Ctr, Zhejiang Canc Res Inst, Hangzhou 310022, Zhejiang, Peoples R China

来源：

HISTOLOGY AND HISTOPATHOLOGY | 2015年 / 30卷 / 10期

关键词：

Isocitrate dehydrogenase 1/2 (IDH1/IDH2); Mutation; Methylation; Metabolism; Tumorigenesis; IDH2; MUTATIONS; ONCOMETABOLITE; 2-HYDROXYGLUTARATE; INHIBITOR;

D O I：

暂无

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

In recent years, frequent isocitrate dehydrogenase 1/2 (IDH1/IDH2) gene mutations were found in a variety of tumors, which specifically alter arginine residues of catalytic active site in IDH1/IDH2 and confer new enzymatic function of directly catalyzing alpha-ketoglutarate (alpha-KG) to R-2-hydroxyglutarate (2HG). 2-HG could competitively inhibit alpha-KG-dependent enzymes and might therefore contribute to tumorigenesis. In addition, mutation status of IDH1/IDH2 is closely related to the progress and prognosis of certain tumors. Thus IDH1/IDH2 is considered to be a promising biomarker for early diagnosis and prognosis and targeted therapy. In this study, the current research on IDH1/IDH2 mutation, especially the mechanisms and clinical characteristics related to tumor, are reviewed.

引用

页码：1155 / 1160

页数：6

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