Position of omalizumab therapy in the treatment of spontaneous chronic urticaria. A case series and literature review

Introduction: Urticaria is an etiopathologically complex disease. Current guidelines recommend an algorithm for urticaria treatment, which includes omalizumab as third line treatment. Objective: To evaluate clinical efficacy of omalizumab in patients with urti-caria. Case report: Three women were treated with omalizumab for spontaneous chronic urticaria, resistant to standard therapy patterns. The concentration of total IgE determined in patients during omalizumab therapy in the first case was originally maintained at a low level, while during the continuation of the treatment it increased four times. In the second case, originally a near 2-fold decrease of total IgE concentration was observed, then it increased 1.5 times. Conclusions: The obtained data confirm a high efficacy of omalizumab the-rapy in patients with spontaneous chronic urticaria. Fast and complete or nearly complete resolution of urticaria symptoms was observed during the treatment.