S100B is downregulated in the nuclear proteome of schizophrenia corpus callosum

被引：17

作者：

Steiner, Johann ^{[1
,2
]}

Schmitt, Andrea ^{[3
,4
]}

Schroeter, Matthias L. ^{[5
,6
]}

Bogerts, Bernhard ^{[1
,2
]}

Falkai, Peter ^{[3
]}

Turck, Christoph W. ^{[7
]}

Martins-de-Souza, Daniel ^{[3
,4
,7
]}

机构：

[1] Univ Magdeburg, Dept Psychiat, D-39106 Magdeburg, Germany

[2] Ctr Behav Brain Sci, Magdeburg, Germany

[3] Ludwig Maximilians Univ Munich LMU, Dept Psychiat & Psychotherapy, Munich, Germany

[4] Univ Sao Paulo, Inst Psychiat, Lab Neurosci LIM 27, Sao Paulo, Brazil

[5] Max Planck Inst Cognit & Human Brain Sci, Leipzig, Germany

[6] Univ Hosp, Clin Cognit Neurol, Leipzig, Germany

[7] Max Planck Inst Psychiat, D-80804 Munich, Germany

来源：

EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE | 2014年 / 264卷 / 04期

基金：

巴西圣保罗研究基金会;

关键词：

S100B; Corpus callosum; White matter; Oligodendrocytes; Proteomics; Mass spectrometry; SERUM-LEVELS; BRAIN; GLIA; CELLS;

D O I：

10.1007/s00406-014-0490-z

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Here we report the downregulation of S100B in the nuclear proteome of the corpus callosum from nine schizophrenia patients compared to seven mentally healthy controls. Our data have been obtained primarily by mass spectrometry and later confirmed by Western blot. This is an intriguing finding coming from a brain region which is essentially composed by white matter, considering the potential role of S100B in the control of oligodendrocyte maturation. This data reinforce the importance of oligodendrocytes in schizophrenia, shedding more light to its pathobiology.

引用

页码：311 / 316

页数：6

共 24 条

[1] Bernstein HG, 2009, EXPERT REV NEUROTHER, V9, P1059, DOI [10.1586/ern.09.59, 10.1586/ERN.09.59]
[2] Nuclear expression of S10013 in oligodendrocyte progenitor cells correlates with differentiation toward the oligodendroglial lineage and modulates oligodendrocytes maturation
Deloulme, JC
Raponi, E
Gentil, BJ
Bertacchi, N
Marks, A
Labourdette, G
Baudier, J
[J]. MOLECULAR AND CELLULAR NEUROSCIENCE, 2004, 27 (04) : 453 - 465
[3] Review of functional and anatomical brain connectivity findings in schizophrenia
Fitzsimmons, Jennifer
Kubicki, Marek
Shenton, Martha E.
[J]. CURRENT OPINION IN PSYCHIATRY, 2013, 26 (02) : 172 - 187
[4] Brain-wide functional inter-hemispheric disconnection is a potential biomarker for schizophrenia and distinguishes it from depression
Guo, Shuixia
Kendrick, Keith M.
Zhang, Jie
Broome, Matthew
Yu, Rongjun
Liu, Zhening
Feng, Jianfeng
[J]. NEUROIMAGE-CLINICAL, 2013, 2 : 818 - 826
[5] Schizophrenia, neurodevelopment and corpus callosum
Innocenti, GM
Ansermet, F
Parnas, J
[J]. MOLECULAR PSYCHIATRY, 2003, 8 (03) : 261 - 274
[6] Jahn T, 1989, Z KLIN PSYCHOL PSYCH, V18, P10
[7] SNPs and haplotypes in the S100B gene reveal association with schizophrenia
Liu, JX
Shi, YY
Tang, JX
Guo, TW
Li, XX
Yang, YF
Chen, QY
Zhao, XZ
He, G
Feng, GY
Gu, NF
Zhu, SM
Liu, HJ
He, L
[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2005, 328 (01) : 335 - 341
[8] Proteome profiling of peripheral mononuclear cells from human blood
Maccarrone, Giuseppina
Rewerts, Christiane
Lebar, Maria
Turck, Christoph W.
Martins-de-Souza, Daniel
[J]. PROTEOMICS, 2013, 13 (05) : 893 - 897
[9] MELTZER HY, 1998, AM PSYCHIAT TXB PSYC, P127
[10] Possible Role of Glia in Cognitive Impairment in Schizophrenia
Mitterauer, Bernhard J.
[J]. CNS NEUROSCIENCE & THERAPEUTICS, 2011, 17 (05) : 333 - 344

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