Evolution and antiviral activity of a human protein of retroviral origin

被引:56
作者
Frank, John A. [1 ]
Singh, Manvendra [1 ]
Cullen, Harrison B. [1 ]
Kirou, Raphael A. [1 ]
Benkaddour-Boumzaouad, Meriem [2 ]
Cortes, Jose L. [2 ,3 ]
Garcia Perez, Jose [2 ,4 ]
Coyne, Carolyn B. [5 ]
Feschotte, Cedric [1 ]
机构
[1] Cornell Univ, Dept Mol Biol & Genet, Ithaca, NY 14850 USA
[2] Univ Granada, Pfizer, GENYO Ctr Genom & Oncol Res, Andalusian Reg Govt,PTS Granada, Granada, Spain
[3] Eppendorf, Iberica, Spain
[4] Univ Edinburgh, Inst Genet & Mol Med, Western Gen Hosp, MRC Human Genet Unit, Edinburgh, Midlothian, Scotland
[5] Duke Univ, Sch Med, Dept Mol Genet & Microbiol, Durham, NC USA
基金
美国国家卫生研究院; 欧洲研究理事会; 英国惠康基金;
关键词
ENDOGENOUS RETROVIRUSES; RECEPTOR; INVOLVEMENT; SUPPRESSYN;
D O I
10.1126/science.abq7871
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Endogenous retroviruses are abundant components of mammalian genomes descended from ancient germline infections. In several mammals, the envelope proteins encoded by these elements protect against exogenous viruses, but this activity has not been documented with endogenously expressed envelopes in humans. We report that the human genome harbors a large pool of envelope-derived sequences with the potential to restrict retroviral infection. To test this, we characterized an envelope-derived protein, Suppressyn. We found that Suppressyn is expressed in human preimplantation embryos and developing placenta using its ancestral retroviral promoter. Cell culture assays showed that Suppressyn, and its hominoid orthologs, could restrict infection by extant mammalian type D retroviruses. Our data support a generalizable model of retroviral envelope co-option for host immunity and genome defense. Copyright © 2022 The Authors, some rights reserved;
引用
收藏
页码:422 / 428
页数:7
相关论文
共 30 条
[1]   Microbial Vertical Transmission during Human Pregnancy [J].
Arora, Nitin ;
Sadovsky, Yoel ;
Dermody, Terence S. ;
Coyne, Carolyn B. .
CELL HOST & MICROBE, 2017, 21 (05) :561-567
[2]   Co-option of an endogenous retrovirus envelope for host defense in hominid ancestors [J].
Blanco-Melo, Daniel ;
Gifford, Robert J. ;
Bieniasz, Paul D. .
ELIFE, 2017, 6
[3]   Characterization of the three HERV-H proviruses with an open envelope reading frame encompassing the immunosuppressive domain and evolutionary history in primates [J].
de Parseval, N ;
Casella, JF ;
Gressin, L ;
Heidmann, T .
VIROLOGY, 2001, 279 (02) :558-569
[4]   Neural Development in Human Embryonic Stem Cells-Applications of Lentiviral Vectors [J].
Dottori, Mirella ;
Tay, Cheryl ;
Hughes, Stephanie M. .
JOURNAL OF CELLULAR BIOCHEMISTRY, 2011, 112 (08) :1955-1962
[5]   LDL receptor and its family members serve as the cellular receptors for vesicular stomatitis virus [J].
Finkelshtein, Danit ;
Werman, Ariel ;
Novick, Daniela ;
Barak, Sara ;
Rubinstein, Menachem .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2013, 110 (18) :7306-7311
[6]   Co-option of endogenous viral sequences for host cell function [J].
Frank, John A. ;
Feschotte, Cedric .
CURRENT OPINION IN VIROLOGY, 2017, 25 :81-89
[7]   Subcellular redistribution of Pit-2 Pi transporter/amphotropic leukemia virus (A-MuLV) receptor in A-MuLV-infected NIH 3T3 fibroblasts:: Involvement in superinfection interference [J].
Jobbagy, Z ;
Garfield, S ;
Baptiste, L ;
Eiden, MV ;
Anderson, WB .
JOURNAL OF VIROLOGY, 2000, 74 (06) :2847-2854
[8]   Origins and evolutionary consequences of ancient endogenous retroviruses [J].
Johnson, Welkin E. .
NATURE REVIEWS MICROBIOLOGY, 2019, 17 (06) :355-370
[9]   Endogenous Retroviruses in the Genomics Era [J].
Johnson, Welkin E. .
ANNUAL REVIEW OF VIROLOGY, VOL 2, 2015, 2 :135-159
[10]  
KIM JW, 1993, J BIOL CHEM, V268, P16316