Synthesis of cis-1,2-Dihalosubstituted 1,7-Octadienes by Pd-Catalyzed Cross-Coupling Reaction in Ionic Liquids

被引：3

作者：

Yang, Shaorong ^{[1
]}

Ling, Changwei ^{[1
]}

Ma, Jianye ^{[1
]}

Zhang, Lei ^{[1
]}

Li, Jianxiao ^{[1
]}

Luo, Wei ^{[2
]}

机构：

[1] S China Univ Technol, Sch Chem & Chem Engn, Guangzhou 510640, Guangdong, Peoples R China

[2] S China Univ Technol, Analyt & Testing Ctr, Guangzhou 510640, Guangdong, Peoples R China

来源：

CHINESE JOURNAL OF ORGANIC CHEMISTRY | 2014年 / 34卷 / 06期

基金：

中国国家自然科学基金;

关键词：

ionic liquids; palladium-catalyst; haloalkynes; hex-5-en-1-ol; cis-1,2-dihalosubstituted alkenes; VINYL HALIDES; STEREOSELECTIVE-SYNTHESIS; ENYNE CYCLIZATION; HIGHLY EFFICIENT; ALKYNES; ALKENES; ACIDS; CYCLOISOMERIZATION; CONSTRUCTION; SUBSTITUTION;

D O I：

10.6023/cjoc201401017

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A Pd-catalyzed method was developed for cross-coupling reaction of a wide range of haloalkynes with hex-5-en-1-ol in ionic liquids. In the presence of PdBr2, [Bmim]X and HXaq, the cross-coupling products can be obtained in moderate to good yields, and the reaction displayed high regio- and stereo-selectivities. Moreover, the reaction is a convenient and simple path for the synthesis of the cis-1,2-dihalosubstituted alkenes, and tolerates several functional groups on haloalkynes.

引用

页码：1148 / 1153

页数：6

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