Cell polarity and actin mRNA localization

被引:1
作者
Lavoie, B
Basyuk, E
Bordonné, R
Bertrand, É
机构
[1] NINDS, Mol Plast Sect, Bethesda, MD 20892 USA
[2] Univ Montpellier 2, IGMM, CNRS, UMR 5535, F-34293 Montpellier 5, France
来源
M S-MEDECINE SCIENCES | 2004年 / 20卷 / 05期
关键词
D O I
10.1051/medsci/2004205539
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
In many species, intracellular mRNA localization is linked to cell polarity. In many cases however, mRNAs become localized as a result of a pre-existing cell-polarity, and they do not modify it. Remarkably, in the case beta actin mRNA in vertebrate, it has been shown that the transport and localization of this RNA is required for the establishment and maintenance of cell polarity. This occurs in fibroblasts, but, very interestingly, in immature neurons as well. This review will describe the functions and mechanisms of actin mRNA localization.
引用
收藏
页码:539 / 543
页数:5
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