Microbes, the gut and ankylosing spondylitis

被引：62

作者：

Costello, Mary-Ellen ^{[1
]}

Elewaut, Dirk ^{[2
]}

Kenna, Tony J. ^{[1
]}

Brown, Matthew A. ^{[1
]}

机构：

[1] Univ Queensland, Diamantina Inst, Translat Res Inst, Princess Alexandra Hosp, Brisbane, Qld 4102, Australia

[2] Ghent Univ Hosp, Dept Rheumatol, Lab Mol Immunol & Inflammat, B-9000 Ghent, Belgium

来源：

ARTHRITIS RESEARCH & THERAPY | 2013年 / 15卷 / 03期

基金：

英国医学研究理事会;

关键词：

INFLAMMATORY-BOWEL-DISEASE; KILLER T-CELLS; ESCHERICHIA-COLI INFECTION; COLLAGEN-INDUCED ARTHRITIS; GENOME-WIDE ASSOCIATION; IMMUNE-RESPONSES; CUTTING EDGE; EXPRESSION; MACROPHAGES; RECEPTOR;

D O I：

10.1186/ar4228

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

It is increasingly clear that the interaction between host and microbiome profoundly affects health. There are 10 times more bacteria in and on our bodies than the total of our own cells, and the human intestine contains approximately 100 trillion bacteria. Interrogation of microbial communities by using classic microbiology techniques offers a very restricted view of these communities, allowing us to see only what we can grow in isolation. However, recent advances in sequencing technologies have greatly facilitated systematic and comprehensive studies of the role of the microbiome in human health and disease. Comprehensive understanding of our microbiome will enhance understanding of disease pathogenesis, which in turn may lead to rationally targeted therapy for a number of conditions, including autoimmunity.

引用

页数：12

共 101 条

[1] Essential role of NKT cells producing IL-4 and IL-13 in the development of allergen-induced airway hyperreactivity [J].

Akbari, O ;

Stock, P ;

Meyer, E ;

Kronenberg, M ;

Sidobre, S ;

Nakayama, T ;

Taniguchi, M ;

Grusby, MJ ;

DeKruyff, RH ;

Umetsu, DT .

NATURE MEDICINE, 2003, 9 (05) :582-588

[2] Epithelial-cell recognition of commensal bacteria and maintenance of immune homeostasis in the gut [J].

Artis, David .

NATURE REVIEWS IMMUNOLOGY, 2008, 8 (06) :411-420

[3] Enterotypes of the human gut microbiome [J].

Arumugam, Manimozhiyan ;

Raes, Jeroen ;

Pelletier, Eric ;

Le Paslier, Denis ;

Yamada, Takuji ;

Mende, Daniel R. ;

Fernandes, Gabriel R. ;

Tap, Julien ;

Bruls, Thomas ;

Batto, Jean-Michel ;

Bertalan, Marcelo ;

Borruel, Natalia ;

Casellas, Francesc ;

Fernandez, Leyden ;

Gautier, Laurent ;

Hansen, Torben ;

Hattori, Masahira ;

Hayashi, Tetsuya ;

Kleerebezem, Michiel ;

Kurokawa, Ken ;

Leclerc, Marion ;

Levenez, Florence ;

Manichanh, Chaysavanh ;

Nielsen, H. Bjorn ;

Nielsen, Trine ;

Pons, Nicolas ;

Poulain, Julie ;

Qin, Junjie ;

Sicheritz-Ponten, Thomas ;

Tims, Sebastian ;

Torrents, David ;

Ugarte, Edgardo ;

Zoetendal, Erwin G. ;

Wang, Jun ;

Guarner, Francisco ;

Pedersen, Oluf ;

de Vos, Willem M. ;

Brunak, Soren ;

Dore, Joel ;

Weissenbach, Jean ;

Ehrlich, S. Dusko ;

Bork, Peer .

NATURE, 2011, 473 (7346) :174-180

[4] Induction of Colonic Regulatory T Cells by Indigenous Clostridium Species [J].

Atarashi, Koji ;

Tanoue, Takeshi ;

Shima, Tatsuichiro ;

Imaoka, Akemi ;

Kuwahara, Tomomi ;

Momose, Yoshika ;

Cheng, Genhong ;

Yamasaki, Sho ;

Saito, Takashi ;

Ohba, Yusuke ;

Taniguchi, Tadatsugu ;

Takeda, Kiyoshi ;

Hori, Shohei ;

Ivanov, Ivaylo I. ;

Umesaki, Yoshinori ;

Itoh, Kikuji ;

Honda, Kenya .

SCIENCE, 2011, 331 (6015) :337-341

[5] Association between alpha beta TCR(+)CD4(-)CD8(-) T-cell deficiency and IDDM in NOD/Lt mice [J].

Baxter, AG ;

Kinder, SJ ;

Hammond, KJL ;

Scollay, R ;

Godfrey, DI .

DIABETES, 1997, 46 (04) :572-582

[6] The biology of NKT cells [J].

Bendelac, Albert ;

Savage, Paul B. ;

Teyton, Luc .

ANNUAL REVIEW OF IMMUNOLOGY, 2007, 25 :297-336

[7] Analysis of CD161 expression on human CD8+ T cells defines a distinct functional subset with tissue-homing properties [J].

Billerbeck, Eva ;

Kang, Yu-Hoi ;

Walker, Lucy ;

Lockstone, Helen ;

Grafmueller, Stefanie ;

Fleming, Vicki ;

Flint, Jonathan ;

Willberg, Chris B. ;

Bengsch, Bertram ;

Seigel, Bianca ;

Ramamurthy, Narayan ;

Zitzmann, Nicole ;

Barnes, Eleanor J. ;

Thevanayagam, Jonarthan ;

Bhagwanani, Anisha ;

Leslie, Alasdair ;

Oo, Ye H. ;

Kollnberger, Simon ;

Bowness, Paul ;

Drognitz, Oliver ;

Adams, David H. ;

Blum, Hubert E. ;

Thimme, Robert ;

Klenerman, Paul .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2010, 107 (07) :3006-3011

[8] MODULATION OF EPITHELIAL-CELL GROWTH BY INTRAEPITHELIAL GAMMA-DELTA T-CELLS [J].

BOISMENU, R ;

HAVRAN, WL .

SCIENCE, 1994, 266 (5188) :1253-1255

[9] Innate lymphoid cells drive interleukin-23-dependent innate intestinal pathology [J].

Buonocore, Sofia ;

Ahern, Philip P. ;

Uhlig, Holm H. ;

Ivanov, Ivaylo I. ;

Littman, Dan R. ;

Maloy, Kevin J. ;

Powrie, Fiona .

NATURE, 2010, 464 (7293) :1371-1375

[10] A large-scale genetic association study confirms IL12B and leads to the identification of IL23R as psoriasis-risk genes [J].

Cargill, Michele ;

Schrodi, Steven J. ;

Chang, Monica ;

Garcia, Veronica E. ;

Brandon, Rhonda ;

Callis, Kristina P. ;

Matsunami, Nori ;

Ardlie, Kristin G. ;

Civello, Daniel ;

Catanese, Joseph J. ;

Leong, Diane U. ;

Panko, Jackie M. ;

McAllister, Linda B. ;

Hansen, Christopher B. ;

Papenfuss, Jason ;

Prescott, Stephen M. ;

White, Thomas J. ;

Leppert, Mark F. ;

Krueger, Gerald G. ;

Begovich, Ann B. .

AMERICAN JOURNAL OF HUMAN GENETICS, 2007, 80 (02) :273-290

← 1 2 3 4 5 6 7 8 9 10 →