Searching for anti-glioma activity. Ribonucleoside analogues with modifications in nucleobase and sugar moieties

被引：7

作者：

Framski, Grzegorz ^{[1
]}

Wawrzyniak, Dariusz ^{[1
]}

Jahnz-Wechmann, Zofia ^{[1
]}

Szymanska-Michalak, Agnieszka ^{[1
]}

Kraszewski, Adam ^{[1
]}

Barciszewski, Jan ^{[1
]}

Boryski, Jerzy ^{[1
]}

Stawinski, Jacek ^{[1
]}

机构：

[1] Polish Acad Sci, Inst Bioorgan Chem, Poznan, Poland

来源：

ACTA BIOCHIMICA POLONICA | 2016年 / 63卷 / 04期

关键词：

ribonucleoside analogues; anti-glioblastoma activity; anticancer ribonucleotides; ADENOSINE RECEPTORS; TRANSGLYCOSYLATION; NUCLEOSIDES; DERIVATIVES; THERAPY; POTENT;

D O I：

10.18388/abp.2016_1338

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Several ribonucleoside analogues with modifications in the nucleobase and sugar moiety have been screened for anti-glioma activity in the T98G glioma cell line using cervical (HeLa) cell line as reference human malignant cells, and lung fibroblast (MCR-5) cell line as non-cancerous reference cells. Among the investigated compounds, ribonucleosides containing 6-chloropurine (3), 7-guanine (5) and a pyrrolopyrimidine (18) as nucleobases, show promising anti-glioma activity with good selectivity indices, and can be considered as lead structures for further anti-cancer studies.

引用

页码：765 / 771

页数：7

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