Clioquinol inhibits the proteasome and displays preclinical activity in leukemia and myeloma

被引：111
作者：
Mao, X. [1 ]
Li, X. [1 ]
Sprangers, R. [2 ,3 ,4 ]
Wang, X. [1 ]
Venugopal, A. [1 ]
Wood, T. [1 ,4 ]
Zhang, Y. [1 ,4 ]
Kuntz, D. A. [1 ]
Coe, E. [1 ]
Trudel, S. [1 ,5 ,6 ]
Rose, D. [1 ,5 ]
Batey, R. A. [4 ]
Kay, L. E. [2 ]
Schimmer, A. D. [1 ,5 ,6 ]
机构：
[1] Princess Margaret Hosp, Ontario Canc Inst, Dept Canc Genom & Prote, Toronto, ON M4X 1K9, Canada
[2] Univ Toronto, Dept Med Genet, Toronto, ON, Canada
[3] Univ Toronto, Dept Biochem, Toronto, ON, Canada
[4] Univ Toronto, Dept Chem, Toronto, ON M5S 1A1, Canada
[5] Univ Toronto, Dept Med Biophys, Toronto, ON, Canada
[6] Univ Toronto, Dept Med, Toronto, ON, Canada
来源：
LEUKEMIA | 2009年 / 23卷 / 03期
关键词：
CRYSTAL-STRUCTURE; 20S PROTEASOME; BORTEZOMIB; DISEASE;
D O I：
10.1038/leu.2008.232
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
[No abstract available]
引用
收藏
页码：585 / 590
页数：7
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