A Pyrene Derivative for Hg2+-Selective Fluorescent Sensing and Its Application in In Vivo Imaging

被引：25

作者：

Wang, Guang Ke ^{[1
]}

Mi, Qi Li ^{[3
,4
]}

Zhao, Li Yun ^{[1
]}

Hu, Jun Jie ^{[5
]}

Guo, Lin E. ^{[1
]}

Zou, Xiao Ju ^{[1
]}

Liu, Bo ^{[2
]}

Xie, Xiao Guang ^{[1
]}

Zhang, Jun Feng ^{[2
]}

Zhao, Qi Hua ^{[1
]}

Zhou, Ying ^{[1
]}

机构：

[1] Yunnan Univ, Sch Chem Sci & Technol, Key Lab Med Chem Nat Resource, Kunming 650091, Peoples R China

[2] Yunnan Normal Univ, Coll Chem & Chem Engn, Kunming 650500, Peoples R China

[3] Yunnan Univ, Yunnan Inst Microbiol, Kunming 650091, Peoples R China

[4] Yunnan Acad Tobacco Sci, Kunming 650106, Peoples R China

[5] Yunnan Univ, Sch Life Sci, Kunming 650091, Peoples R China

来源：

CHEMISTRY-AN ASIAN JOURNAL | 2014年 / 9卷 / 03期

关键词：

fluorescent probes; in vivo imaging; mercury; molecular recognition; sensors; TURN-ON; COLORIMETRIC CHEMOSENSORS; RECENT PROGRESS; SENSOR; HG2+; WATER; IONS;

D O I：

10.1002/asia.201301123

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

An Hg2+-selective fluorescent sensor (1) bearing pyrene as a fluorophore was synthesized. A sandwich-stacking binding mode was formed during the binding process, which increased the excimer fluorescence 22-fold at 490nm. Compound 1 was successfully applied in in vivo imaging to trace the enrichment and distribution of mercury in the nervous system, digestive system, and reproductive system of Caenorhabditis elegans, as well as the organs of zebrafish.

引用

页码：744 / 748

页数：5

共 32 条

[1] AROMATIC-AROMATIC INTERACTION - A MECHANISM OF PROTEIN-STRUCTURE STABILIZATION [J].

BURLEY, SK ;

PETSKO, GA .

SCIENCE, 1985, 229 (4708) :23-28

[2] Real-time in vivo imaging of mercury uptake in Caenorhabditis elegans through the foodchain [J].

Chapleau, Richard R. ;

Sagermann, Martin .

TOXICOLOGY, 2009, 261 (03) :136-142

[3] Hg2+ Selective Fluorescent and Colorimetric Sensor: Its Crystal Structure and Application to Bioimaging [J].

Chen, Xiaoqiang ;

Nam, Seong-Won ;

Jou, Min Jung ;

Kim, Youngmee ;

Kim, Sung-Jin ;

Park, Sungsu ;

Yoon, Juyoung .

ORGANIC LETTERS, 2008, 10 (22) :5235-5238

[4] A near-infrared fluorescent sensor for detection of cyanide in aqueous solution and its application for bioimaging [J].

Chen, Xiaoqiang ;

Nam, Seong-Won ;

Kim, Gun-Hee ;

Song, Nari ;

Jeong, Yongsuk ;

Shin, Injae ;

Kim, Seog K. ;

Kim, Jinheung ;

Park, Sungsu ;

Yoon, Juyoung .

CHEMICAL COMMUNICATIONS, 2010, 46 (47) :8953-8955

[5] A thiol-specific fluorescent probe and its application for bioimaging [J].

Chen, Xiaoqiang ;

Ko, Sung-Kyun ;

Kim, Min Jung ;

Shin, Injae ;

Yoon, Juyoung .

CHEMICAL COMMUNICATIONS, 2010, 46 (16) :2751-2753

[6]

Frisch M. J., 2016, Gaussian 03 Revision B.03

[7] PHOTOIONOPHORES DERIVED FROM CROWN-ETHER POLYCARBOXYLIC ACIDS - SYNTHESIS, ION-BINDING, AND SPECTROSCOPIC CHARACTERIZATION [J].

FYLES, TM ;

SURESH, VV .

CANADIAN JOURNAL OF CHEMISTRY-REVUE CANADIENNE DE CHIMIE, 1994, 72 (05) :1246-1253

[8] Boron based anion receptors as sensors [J].

Galbraith, Ewan ;

James, Tony D. .

CHEMICAL SOCIETY REVIEWS, 2010, 39 (10) :3831-3842

[9] Impact of Donor-Acceptor Geometry and Metal Chelation on Photophysical Properties and Applications of Triarylboranes [J].

Hudson, Zachary M. ;

Wang, Suning .

ACCOUNTS OF CHEMICAL RESEARCH, 2009, 42 (10) :1584-1596

[10] Attractive intramolecular edge-to-face aromatic interactions in flexible organic molecules [J].

Jennings, WB ;

Farrell, BM ;

Malone, JF .

ACCOUNTS OF CHEMICAL RESEARCH, 2001, 34 (11) :885-894

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