Acute Changes in Thyroid Hormone Levels among Thai Pesticide Sprayers

被引：21

作者：

Kongtip, Pornpimol ^{[1
,2
]}

Nankongnab, Noppanun ^{[1
,2
]}

Pundee, Ritthirong ^{[3
]}

Kallayanatham, Nichcha ^{[1
]}

Pengpumkiat, Sumate ^{[1
]}

Chungcharoen, Jutamanee ^{[1
]}

Phommalachai, Chavisa ^{[1
]}

Konthonbut, Pajaree ^{[1
]}

Choochouy, Nattagorn ^{[4
]}

Sowanthip, Preecha ^{[2
]}

Khangkhun, Phanthawee ^{[5
]}

Yimsabai, Jutharak ^{[6
]}

Woskie, Susan ^{[7
]}

机构：

[1] Mahidol Univ, Fac Publ Hlth, Dept Occupat Hlth & Safety, 420-1 Rajvidhi Rd, Bangkok 10400, Thailand

[2] EHT, Ctr Excellence Environm Hlth & Toxicol, Bangkok 10400, Thailand

[3] Mahidol Univ, Nakhonsawan Campus, Nakhonsawan 60130, Thailand

[4] Thammasat Univ Lampang Campus, Fac Publ Hlth, Lampang 52190, Thailand

[5] Minist Publ Hlth, Dept Hlth, Bur Elderly Hlth, Nonthaburi 11000, Thailand

[6] Buddhachinaraj Phitsanulok Hosp, Dept Med Technol & Clin Pathol, 90 Sithamma Traipidok Rd, Phitsanulok 65000, Thailand

[7] Univ Massachusetts, Dept Publ Hlth, One Univ Ave, Lowell, MA 01854 USA

来源：

TOXICS | 2021年 / 9卷 / 01期

关键词：

cypermethrin; paraquat; glyphosate; chlorpyrifos; thyroid hormones; acute exposure; farmers; pesticides; endocrine disrupter;

D O I：

10.3390/toxics9010016

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

The objective of this study was to investigate the relationship of acute pesticide exposures and acute changes in thyroid hormones among Thai farmers. We recruited 78 farmers, who were scheduled to spray insecticides (chlorpyrifos and/or cypermethrin) or herbicides (paraquat and/or glyphosate). On the day before spraying, farmers collected their first morning void urine and went for blood collection. On the spray day, urine samples were collected at end of the spraying event and they were interviewed with questionnaires. The next morning, the first morning void urine and blood samples were collected. Blood samples were analyzed for thyroid hormones. Urine samples were analyzed for the metabolites of the pesticide sprayed. The results showed that the thyroid hormones, free triiodothyronine (FT3) and total triiodothyronine (T3) were significantly reduced as urinary chlorpyrifos metabolite increased the day after spraying. Total thyroxine (T4) significantly increased as cypermethrin metabolites increased the day after spraying. T4 significantly increased as urinary glyphosate levels increased; however, FT3 and T3 decreased significantly as urinary paraquat levels increased the day after spraying. These findings suggest that acute exposures to the pesticides chlorpyrifos, cypermethrin, paraquat and glyphosate can produce acute effects on the hypothalamic-pituitary-thyroid (HPT) axis, acutely altering thyroid hormone levels.

引用

页码：1 / 16

页数：16

共 71 条

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