Antagonistic action of orphanin FQ on acupuncture analgesia in rat brain

被引：22

作者：

Zhu, CB

Xu, SF

Cao, XD

Wu, GC

Zhang, XL

Li, MY

Cui, DF

Chi, CW

机构：

[1] Natl. Key Lab. of Med. Neurobiology, Shanghai Medical University, Shanghai 200032, Shanghai

[2] Jinan Mil. Med. Sch. Shangdong Prov., Jinan, Shangdong

[3] Shanghai Institute of Biochemistry, Chinese Academy of Sciences

来源：

ACUPUNCTURE & ELECTRO-THERAPEUTICS RESEARCH | 1996年 / 21卷 / 3-4期

关键词：

orphanin FQ(OFQ); OFQ receptor; electroacupuncture analgesia;

D O I：

10.3727/036012996816356852

中图分类号：

R [医药、卫生];

学科分类号：

10 ;

摘要：

The influence of orphanin FQ (OFQ) ( a newly discovered 17-amino acid peptide) on acupuncture analgesia (AA) was assessed in rat tail-flick model. Intracerebroventricular (icv) injection of OFQ(1 mu g) elicited a significant decrement of pain threshold which was abolished by the repeated pretreatment with antisense oligonucleotide (ASO) to OFQ receptor. Electroacupuncture (EA) induced an obvious analgesic effect; when OFQ was used combined with EA, it showed a dose-dependent effect on antagonizing the EA analgesia. When rat was repeatedly icy injected with ASO to block the synthesis of OFQ receptor, the EA analgesia was enhanced markedly. In this instance, the OFQ did not show antagonistic effect on EA analgesia any more. The results suggest that the OFQ play its antagonistic role on EA analgesia via activating OFQ receptor.

引用

页码：199 / 205

页数：7

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