Croconaine rotaxane for acid activated photothermal heating and ratiometric photoacoustic imaging of acidic pH

被引：78
|
作者：
Guha, Samit [1 ]
Shaw, Gillian Karen [1 ]
Mitcham, Trevor M. [2 ]
Bouchard, Richard R. [2 ]
Smith, Bradley D. [1 ]
机构：
[1] Univ Notre Dame, Dept Chem & Biochem, Notre Dame, IN 46556 USA
[2] Univ Texas MD Anderson Canc Ctr, Dept Imaging Phys, Houston, TX 77054 USA
来源：
CHEMICAL COMMUNICATIONS | 2016年 / 52卷 / 01期
关键词：
GOLD NANOPARTICLES; DOPED NANOPARTICLES; INDUCED AGGREGATION; LIPOSOMES; DRUG; NANOMATERIALS; ACIDIFICATION; STRATEGIES; NANOPROBE; RELEASE;
D O I：
10.1039/c5cc08317f
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Absorption of 808 nm laser light by liposomes containing a pH sensitive, near-infrared croconaine rotaxane dye increases dramatically in weak acid. A stealth liposome composition permits acid activated, photothermal heating and also acts as an effective nanoparticle probe for ratiometric photoacoustic imaging of acidic pH in deep sample locations, including a living mouse.
引用
收藏
页码：120 / 123
页数：4
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