Silver-Catalyzed Reaction of Enynals with Alkenes: A Tandem 1,3-Dipolar Cycloaddition/Cyclopropanation

被引：67

作者：

Liang, Renxiao ^{[1
]}

Ma, Tongmei ^{[1
]}

Zhu, Shifa ^{[1
]}

机构：

[1] S China Univ Technol, Sch Chem & Chem Engn, Guangzhou 510640, Guangdong, Peoples R China

来源：

ORGANIC LETTERS | 2014年 / 16卷 / 17期

基金：

中央高校基本科研业务费专项资金资助;

关键词：

AZA-COPE REARRANGEMENTS; ORGANOMETALLIC COMPOUNDS; THERMAL-DECOMPOSITION; CYCLIZATION REACTIONS; EFFICIENT SYNTHESIS; CARBENE INSERTION; VINYLIC COPPER(I); BOND; ALLENES; FURANS;

D O I：

10.1021/ol5017299

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A silver-catalyzed reaction of enynals with alkenes to synthesize a series of polycyclic compounds has been developed. The reaction occurred smoothly using enynals with electron-deficient alkynes or terminal alkynes as substrates. The reaction was proposed to proceed through a tandem 1,3-dipolar cycloaddition/cyclopropanation process. The preliminary investigations of the asymmetric catalytic version revealed that the biphosphine ligand could be used as the potential efficient chiral ligand.

引用

页码：4412 / 4415

页数：4

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