Reproductive Hormone Influences on Thermoregulation in Women

被引:108
作者
Charkoudian, Nisha [1 ]
Stachenfeld, Nina S. [2 ,3 ,4 ]
机构
[1] US Army Res Inst Environm Med, Natick, MA USA
[2] Yale Univ, Sch Med, Dept Obstet Gynecol & Reprod Sci, New Haven, CT 06520 USA
[3] Yale Univ, Sch Med, Sch Publ Hlth, New Haven, CT USA
[4] John B Pierce Lab, New Haven, CT USA
关键词
SKIN BLOOD-FLOW; GANIRELIX ANTAGON/ORGALUTRAN-ASTERISK; ACTIVE CUTANEOUS VASODILATION; HEALTHY FEMALE VOLUNTEERS; HUMAN MENSTRUAL-CYCLE; UP HERS-II; REFLEX CONTROL; PHARMACODYNAMIC CHARACTERISTICS; ESTROGEN/PROGESTIN REPLACEMENT; THERMOEFFECTOR RESPONSES;
D O I
10.1002/cphy.c130029
中图分类号
Q4 [生理学];
学科分类号
071003 ;
摘要
The present discussion reviews current knowledge regarding influences of the primary reproductive hormones on mechanisms of thermoregulatory control in women. The human body is remarkably capable of maintaining body temperature within a few tenths of a degree of normal (37 degrees C) over a wide range of activity and environmental exposures; this regulation is accomplished via integration of central and peripheral thermal information at the preoptic area of the anterior hypothalamus (PO/AH). We describe both central and peripheral mechanisms involved in controlling thermoregulation in humans, and how these mechanisms are affected by sex and hormone exposure. Estrogens generally promote vasodilation, heat dissipation, and lower body temperature and progesterone or progestins generally have the opposite effect. Estrogens and progesterone/progestins can also interact with androgens; this is an important point because androgens in the body can increase in both older and younger women. The study of reproductive hormone (estrogens, progesterone, luteinizing, and follicle stimulating hormones) effects on body systems is challenging because of the complex and multifaceted influences of these hormones, both individually and in combination. Thus, a number of methods to alter hormone exposure are explained in this article. We conclude that men and women do not exhibit major quantitative differences in physiological thermoregulatory responses to exercise and/or body heating when factors such as fitness and body size are taken into account. However, female and male reproductive hormones have important influences that can significantly alter individual thermoregulatory responses at various points throughout the lifespan.
引用
收藏
页码:793 / 804
页数:12
相关论文
共 76 条
[1]  
[Anonymous], WHAT DO WE MEAN SEX
[2]  
[Anonymous], NIH POL GUID INCL WO
[3]   Neuronal basis of Hammel's model for set-point thermoregulation [J].
Boulant, JA .
JOURNAL OF APPLIED PHYSIOLOGY, 2006, 100 (04) :1347-1354
[4]   Chronic hormone replacement therapy does not alter resting or maximal skin blood flow [J].
Brooks-Asplund, EM ;
Kenney, WL .
JOURNAL OF APPLIED PHYSIOLOGY, 1998, 85 (02) :505-510
[5]   Influence of hormone replacement therapy and aspirin on temperature regulation in postmenopausal women [J].
Brooks-Asplund, EM ;
Cannon, JG ;
Kenney, WL .
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY, 2000, 279 (03) :R839-R848
[6]   PHYSIOLOGICAL REACTIONS OF MEN AND WOMEN DURING MUSCULAR ACTIVITY AND RECOVERY IN VARIOUS ENVIRONMENTS [J].
BROUHA, L ;
DELANNE, R ;
SMITH, PE ;
MAXFIELD, ME .
JOURNAL OF APPLIED PHYSIOLOGY, 1961, 16 (01) :133-&
[7]   A prospective longitudinal study of serum testosterone, dehydroepiandrosterone sulfate, and sex hormone-binding globulin levels through the menopause transition [J].
Burger, HG ;
Dudley, EC ;
Cui, JS ;
Dennerstein, L ;
Hopper, JL .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2000, 85 (08) :2832-2838
[8]   Effect of estrogen supplementation on exercise thermoregulation in premenopausal women [J].
Chang, RT ;
Lambert, GP ;
Moseley, PL ;
Chapler, FK ;
Gisolfi, CV .
JOURNAL OF APPLIED PHYSIOLOGY, 1998, 85 (06) :2082-2088
[9]   Reflex control of cutaneous vasoconstrictor system is reset by exogenous female reproductive hormones [J].
Charkoudian, N ;
Johnson, JM .
JOURNAL OF APPLIED PHYSIOLOGY, 1999, 87 (01) :381-385
[10]   Altered reflex control of cutaneous circulation by female sex steroids is independent of prostaglandins [J].
Charkoudian, N ;
Johnson, JM .
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 1999, 276 (05) :H1634-H1640