Transition-metal free 2-arylbenzoxazole formation from aryl amides and cyclohexanones

被引：57
作者：
Cao, Xiangxiang [1 ]
Cheng, Xiufang [1 ]
Bai, Yang [1 ]
Liu, Saiwen [1 ]
Deng, Guo-Jun [1 ,2 ]
机构：
[1] Xiangtan Univ, Coll Chem, Minist Educ, Key Lab Environm Friendly Chem & Applicat, Xiangtan 411105, Peoples R China
[2] Chinese Acad Sci, Inst Chem, Key Lab Mol Recognit & Funct, Beijing 100080, Peoples R China
来源：
GREEN CHEMISTRY | 2014年 / 16卷 / 11期
基金：
高等学校博士学科点专项科研基金; 中国国家自然科学基金;
关键词：
CATALYZED DIRECT ARYLATION; C-H ARYLATION; AEROBIC DEHYDROGENATION; ARYLBORONIC ACIDS; BOND FORMATION; BENZOXAZOLES; HETEROARENES; EFFICIENT; AZOLES; BENZOTHIAZOLES;
D O I：
10.1039/c4gc01572j
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A transition-metal-free method for the synthesis of 2-arylbenzoxazoles from readily available cyclohexanones and benzamides is described. The combined use of KI, p-TsOH and DMSO significantly improved the reaction yields. Non-aromatic cyclohexanones were smoothly dehydrogenated and acted as the aryl source using oxygen as the oxidant.
引用
收藏
页码：4644 / 4648
页数：5
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