Transition-metal free 2-arylbenzoxazole formation from aryl amides and cyclohexanones

被引：57

作者：

Cao, Xiangxiang ^{[1
]}

Cheng, Xiufang ^{[1
]}

Bai, Yang ^{[1
]}

Liu, Saiwen ^{[1
]}

Deng, Guo-Jun ^{[1
,2
]}

机构：

[1] Xiangtan Univ, Coll Chem, Minist Educ, Key Lab Environm Friendly Chem & Applicat, Xiangtan 411105, Peoples R China

[2] Chinese Acad Sci, Inst Chem, Key Lab Mol Recognit & Funct, Beijing 100080, Peoples R China

来源：

GREEN CHEMISTRY | 2014年 / 16卷 / 11期

基金：

中国国家自然科学基金; 高等学校博士学科点专项科研基金;

关键词：

CATALYZED DIRECT ARYLATION; C-H ARYLATION; AEROBIC DEHYDROGENATION; ARYLBORONIC ACIDS; BOND FORMATION; BENZOXAZOLES; HETEROARENES; EFFICIENT; AZOLES; BENZOTHIAZOLES;

D O I：

10.1039/c4gc01572j

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A transition-metal-free method for the synthesis of 2-arylbenzoxazoles from readily available cyclohexanones and benzamides is described. The combined use of KI, p-TsOH and DMSO significantly improved the reaction yields. Non-aromatic cyclohexanones were smoothly dehydrogenated and acted as the aryl source using oxygen as the oxidant.

引用

页码：4644 / 4648

页数：5

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