Palladium-Catalyzed Hydroxylation of Aryl and Heteroaryl Halides Enabled by the Use of a Palladacycle Precatalyst

被引：61
|
作者：
Cheung, Chi Wai [1 ]
Buchwald, Stephen L. [1 ]
机构：
[1] MIT, Dept Chem, Cambridge, MA 02139 USA
来源：
JOURNAL OF ORGANIC CHEMISTRY | 2014年 / 79卷 / 11期
基金：
美国国家卫生研究院;
关键词：
HIGHLY EFFICIENT SYNTHESIS; ARYLBORONIC ACIDS; OXIDATIVE HYDROXYLATION; FUNCTIONAL-GROUPS; NATURAL-PRODUCTS; PHENOLS; ETHERS; BORYLATION; DERIVATIVES; HYDROXIDE;
D O I：
10.1021/jo500662s
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A method for the hydroxylation of aryl and heteroaryl halides, promoted by a catalyst based on a biarylphosphine ligand tBuBrettPhos (1,5) and its corresponding palladium precatalyst (1), is described. The reactions allow the cross-coupling of both potassium and cesium hydroxides with (hetero)aryl halides to afford a variety of phenols and hydroxylated heteroarenes in high to excellent yield.
引用
收藏
页码：5351 / 5358
页数：8
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