FNIH-defined Sarcopenia Predicts Adverse Outcomes Among Community-Dwelling Older People in Taiwan: Results From I-Lan Longitudinal Aging Study

被引:46
作者
Tang, Ting-Ching [1 ,2 ]
Hwang, An-Chun [1 ,2 ,3 ]
Liu, Li-Kuo [1 ,2 ]
Lee, Wei-Ju [2 ,3 ,4 ]
Chen, Liang-Yu [1 ,2 ,3 ]
Wu, Yi-Hui [1 ,2 ]
Huang, Chung-Yu [1 ,2 ,3 ]
Hung, Cheng-Hao [1 ,2 ,3 ]
Wang, Chih-Jen [1 ,2 ,5 ]
Lin, Ming-Hsien [1 ,2 ]
Peng, Li-Ning [1 ,2 ,3 ]
Chen, Liang-Kung [1 ,2 ]
机构
[1] Taipei Vet Gen Hosp, Ctr Geriatr & Gerontol, 201,Sec 2,Shih Pai Rd, Taipei 11217, Taiwan
[2] Natl Yang Ming Univ, Aging & Hlth Res Ctr, Taipei, Taiwan
[3] Natl Yang Ming Univ, Inst Publ Hlth, Taipei, Taiwan
[4] Taipei Vet Gen Hosp, Dept Family Med, Yuanshan Branch, Yuanshan, Taiwan
[5] Changhua Christian Hosp, Dept Med, Changhua, Taiwan
来源
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES | 2018年 / 73卷 / 06期
关键词
Aging; All-cause mortality; Sarcopenia; The foundation for the National Institute of Health Biomarkers Consortium Sarcopenia Project; OSTEOPOROTIC FRACTURES; PHYSICAL FUNCTION; LEAN MASS; OBESITY; HEALTH; ASSOCIATION; PREVALENCE; SURVIVAL; ADULTS; WOMEN;
D O I
10.1093/gerona/glx148
中图分类号
R592 [老年病学]; C [社会科学总论];
学科分类号
03 ; 0303 ; 100203 ;
摘要
Background: To evaluate the predictive validity of sarcopenia defined by the Foundation for the National Institutes of Health (FNIH) Sarcopenia Project among Asian older adults. Methods: Data of the I-Lan Longitudinal Aging Study were obtained for analysis. Overall, 1,839 community-dwelling people aged 50 years and older, capable of completing a 6-m walk, with life expectancy of more than 6 months, and not institutionalized at time of data collection were enrolled for study. Data for subjects aged 65 years and older were obtained for study. The outcome measures were all-cause mortality and a composite adverse outcome which includes hospitalizations, emergency department visits, institutionalization, and falls. Results: Data of 728 eligible elderly participants (73.4 +/- 5.4 years; 52.9% males) were analyzed. The prevalence of FNIH-diagnosed sarcopenia was 9.5%: 11.9% males; 6.7% females. Participants having FM-I-defined sarcopenia were considerably older, frailer, more obese, with poorer physical performance than nonsarcopenic subjects (All p < .001); during mean follow-up of 32.9 +/- 8.8 months, they also had 3.8 times higher risk of dying, independent of age, sex, multimorbidity, cognitive function, and nutritional status (hazard ratio = 3.8; 95% confidence interval = 1.26-11.45; p = .018). Moreover, sarcopenia defined by grip strength-BMI ratio (Weak(BMI)) showed stronger association with composite adverse outcomes than traditional handgrip strength (hazard ratio = 1.99; 95% confidence interval = 1.01-3.93; p = .047 vs hazard ratio = 1.80; 95% confidence interval = 0.89-3.62; p = .102 in fully-adjusted model). Conclusion: Among community-dwelling older people in Thiwan, participants with FNIH-defined sarcopenia had a significantly greater risk of all-cause mortality and composite falls, emergency department visits, institutionalization, and hospitalization.
引用
收藏
页码:828 / 834
页数:7
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