Blood pressure and risk of cancer progression - A possible connection with salt and voltage-gated sodium channel

被引：7
作者：
Djamgoz, Mustafa B. A. [1 ,2 ]
机构：
[1] Univ London Imperial Coll Sci Technol & Med, Dept Life Sci, Neurosci Solut Canc Res Grp, London SW7 2AZ, England
[2] Cyprus Int Univ, Biotechnol Res Ctr, Nicosia, North Cyprus, Cyprus
来源：
MEDICAL HYPOTHESES | 2015年 / 85卷 / 05期
关键词：
NA+ CHANNELS; EXPRESSION; INVASION; HYPERTENSION; MORTALITY; BLOCKERS; DISEASE; CELLS; WOMEN;
D O I：
10.1016/j.mehy.2015.07.021
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Although it is well known that high blood pressure promotes cancer, the underlying cause(s) is not well understood. Here, we advance the hypothesis that the extracellular sodium level could be a contributing factor. The hypothesis is based upon emerging evidence showing (i) that voltage-gated sodium channels are expressed de novo in cancer cells and tissues, and (ii) that the influx of sodium from the extracellular medium into cancer cells, mediated by the channel activity, promotes their metastatic potential. Clinical and lifestyle implications of the hypothesis are discussed. (C) 2015 Elsevier Ltd. All rights reserved.
引用
收藏
页码：591 / 593
页数：3
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